Evaluating a novel MR-compatible foot pedal device for unipedal and bipedal motion: Test-retest reliability of evoked brain activity.
Hum Brain Mapp
; 42(1): 128-138, 2021 01.
Article
in En
| MEDLINE
| ID: mdl-33089953
ABSTRACT
The purpose of this study was to develop and evaluate a new, open-source MR-compatible device capable of assessing unipedal and bipedal lower extremity movement with minimal head motion and high test-retest reliability. To evaluate the prototype, 20 healthy adults participated in two magnetic resonance imaging (MRI) visits, separated by 2-6 months, in which they performed a visually guided dorsiflexion/plantar flexion task with their left foot, right foot, and alternating feet. Dependent measures included evoked blood oxygen level-dependent (BOLD) signal in the motor network, head movement associated with dorsiflexion/plantar flexion, the test-retest reliability of these measurements. Left and right unipedal movement led to a significant increase in BOLD signal compared to rest in the medial portion of the right and left primary motor cortex (respectively), and the ipsilateral cerebellum (FWE corrected, p < .001). Average head motion was 0.10 ± 0.02 mm. The test-retest reliability was high for the functional MRI data (intraclass correlation coefficients [ICCs] >0.75) and the angular displacement of the ankle joint (ICC 0.842). This bipedal device can robustly isolate activity in the motor network during alternating plantarflexion and dorsiflexion with minimal head movement, while providing high test-retest reliability. Ultimately, these data and open-source building instructions will provide a new, economical tool for investigators interested in evaluating brain function resulting from lower extremity movement.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Psychomotor Performance
/
Cerebellum
/
Head Movements
/
Lower Extremity
/
Diagnostic Techniques, Neurological
/
Equipment Design
/
Functional Neuroimaging
/
Motor Activity
/
Motor Cortex
/
Nerve Net
Type of study:
Evaluation_studies
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
En
Journal:
Hum Brain Mapp
Journal subject:
CEREBRO
Year:
2021
Document type:
Article
Affiliation country:
United States