Preoperative intravenous meloxicam for moderate-to-severe pain in the immediate post-operative period: a Phase IIIb randomized clinical trial in 55 patients undergoing primary open or laparoscopic colorectal surgery with bowel resection and/or anastomosis.
Pain Manag
; 11(1): 9-21, 2021 Jan.
Article
in En
| MEDLINE
| ID: mdl-33094682
ABSTRACT
Aim:
Evaluate safety/efficacy of intravenous meloxicam in a colorectal enhanced recovery after surgery protocol.Methods:
Adults undergoing primary open or laparoscopic colorectal surgery with bowel resection and/or anastomosis received meloxicam IV 30 mg (n = 27) or placebo (n = 28) once daily beginning 30 min before surgery.Results:
Adverse events meloxicam IV, 85%; placebo, 93%. Adverse events commonly associated with opioids 41 versus 61% - including nausea (33 vs 50%), vomiting (19 vs 18%) and ileus (4 vs 18%). Wound healing satisfaction scores (physician-rated), clinical laboratory findings and vital signs were similar in both groups. No anastomotic leaks were reported. Opioid consumption, postoperative pain intensity, length of stay and times to first bowel sound, first flatus and first bowel movement were significantly lower with meloxicam IV versus placebo. Most subjects (>92%) were satisfied with postoperative pain medication.Conclusion:
Meloxicam IV was generally well tolerated and associated with decreased opioid consumption, lower resource utilization and functional benefits. Clinical Trial Registration NCT03323385 (ClinicalTrials.gov).Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pain, Postoperative
/
Anti-Inflammatory Agents, Non-Steroidal
/
Outcome Assessment, Health Care
/
Colectomy
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Meloxicam
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Proctectomy
Type of study:
Clinical_trials
/
Etiology_studies
/
Guideline
Limits:
Adult
/
Aged
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Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Pain Manag
Year:
2021
Document type:
Article
Affiliation country:
United States
Publication country:
ENGLAND
/
ESCOCIA
/
GB
/
GREAT BRITAIN
/
INGLATERRA
/
REINO UNIDO
/
SCOTLAND
/
UK
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UNITED KINGDOM