Metabolic defects in splenic B cell compartments from patients with liver cirrhosis.
Cell Death Dis
; 11(10): 915, 2020 10 24.
Article
in En
| MEDLINE
| ID: mdl-33099582
ABSTRACT
Liver cirrhosis is associated with defective vaccine responses and increased infections. Dysregulated B cell compartments in cirrhotic patients have been noticed but not well characterized, especially in the spleen. Here, we comprehensively investigated B cell perturbations from the spleens and peripheral blood of cirrhotic patients. We found that liver cirrhosis significantly depleted both switched and nonswitched splenic memory B cells, which was further confirmed histologically. Bulk RNA-seq revealed significant metabolic defects as the potential mechanism for the impaired splenic B cell functions. Functionally, the splenic memory B cells from cirrhotic patients showed strong metabolic defects and reduced proliferation compared with those from healthy controls. Thus, liver cirrhosis extensively disturbs the splenic and peripheral B cell compartments, which may contribute to defective humoral immunity during liver cirrhosis.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Spleen
/
B-Lymphocytes
/
Liver Cirrhosis
/
Metabolic Diseases
Limits:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Cell Death Dis
Year:
2020
Document type:
Article
Affiliation country:
China