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Glycosylation decreases aggregation and immunogenicity of adalimumab Fab secreted from Pichia pastoris.
Nakamura, Hitomi; Kiyoshi, Masato; Anraku, Makoto; Hashii, Noritaka; Oda-Ueda, Naoko; Ueda, Tadashi; Ohkuri, Takatoshi.
Affiliation
  • Nakamura H; Faculty of Pharmaceutical Sciences, Sojo University, 4-22-1 Ikeda, Nishi-ku, Kumamoto 860-0082, Japan.
  • Kiyoshi M; Division of Biological Chemistry and Biologicals, National Institute of Health Sciences, 3-25-26, Tonomachi, Kawasaki-ku, Kawasaki, Kanagawa 210-9501, Japan.
  • Anraku M; Faculty of Pharmaceutical Sciences, Sojo University, 4-22-1 Ikeda, Nishi-ku, Kumamoto 860-0082, Japan.
  • Hashii N; Division of Biological Chemistry and Biologicals, National Institute of Health Sciences, 3-25-26, Tonomachi, Kawasaki-ku, Kawasaki, Kanagawa 210-9501, Japan.
  • Oda-Ueda N; Faculty of Pharmaceutical Sciences, Sojo University, 4-22-1 Ikeda, Nishi-ku, Kumamoto 860-0082, Japan.
  • Ueda T; Department of Protein Structure, Function and Design, Graduate School of Pharmaceutical Sciences, Kyushu University, Higashi-ku, Fukuoka 812-8582, Japan.
  • Ohkuri T; Faculty of Pharmaceutical Sciences, Sojo University, 4-22-1 Ikeda, Nishi-ku, Kumamoto 860-0082, Japan.
J Biochem ; 169(4): 435-443, 2021 Apr 29.
Article in En | MEDLINE | ID: mdl-33107910
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Immunoglobulin Fab Fragments / Saccharomycetales / Protein Aggregates / Adalimumab Limits: Animals Language: En Journal: J Biochem Year: 2021 Document type: Article Affiliation country: Japan
Fulltext
Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Immunoglobulin Fab Fragments / Saccharomycetales / Protein Aggregates / Adalimumab Limits: Animals Language: En Journal: J Biochem Year: 2021 Document type: Article Affiliation country: Japan