Naturally occurring hotspot cancer mutations in G&#945;<sub>13</sub> promote oncogenic signaling.

Maziarz, Marcin; Federico, Anthony; Zhao, Jingyi; Dujmusic, Lorena; Zhao, Zhiming; Monti, Stefano; Varelas, Xaralabos; Garcia-Marcos, Mikel

Naturally occurring hotspot cancer mutations in Gα₁₃ promote oncogenic signaling.

Maziarz, Marcin; Federico, Anthony; Zhao, Jingyi; Dujmusic, Lorena; Zhao, Zhiming; Monti, Stefano; Varelas, Xaralabos; Garcia-Marcos, Mikel.

Affiliation

Maziarz M; Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts, USA.
Federico A; Section of Computational Biomedicine, Boston University School of Medicine, Boston, Massachusetts, USA.
Zhao J; Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts, USA.
Dujmusic L; Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts, USA.
Zhao Z; Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts, USA.
Monti S; Section of Computational Biomedicine, Boston University School of Medicine, Boston, Massachusetts, USA.
Varelas X; Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts, USA.
Garcia-Marcos M; Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts, USA. Electronic address: mgm1@bu.edu.

J Biol Chem ; 295(49): 16897-16904, 2020 12 04.

Article in En | MEDLINE | ID: mdl-33109615

Subject(s)

Carcinogenesis/genetics; GTP-Binding Protein alpha Subunits, G12-G13/genetics; Signal Transduction; ADP Ribose Transferases/pharmacology; Acyltransferases; Adaptor Proteins, Signal Transducing/antagonists & inhibitors; Adaptor Proteins, Signal Transducing/genetics; Adaptor Proteins, Signal Transducing/metabolism; Animals; Botulinum Toxins/pharmacology; GTP-Binding Protein alpha Subunits, G12-G13/metabolism; HEK293 Cells; Humans; Mice; Mutagenesis, Site-Directed; NIH 3T3 Cells; RNA Interference; RNA, Small Interfering/metabolism; Rho Guanine Nucleotide Exchange Factors/metabolism; Transcription Factors/antagonists & inhibitors; Transcription Factors/genetics; Transcription Factors/metabolism; Transcriptional Activation/drug effects; Up-Regulation; Urinary Bladder Neoplasms/genetics; Urinary Bladder Neoplasms/metabolism; Urinary Bladder Neoplasms/pathology; YAP-Signaling Proteins; rho GTP-Binding Proteins/metabolism

Key words

Bladder Cancer; G-protein; G-protein-coupled receptor (GPCR); GTPase; cancer biology; oncogene

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Signal Transduction / GTP-Binding Protein alpha Subunits, G12-G13 / Carcinogenesis Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Biol Chem Year: 2020 Document type: Article Affiliation country: United States

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