ROS Overproduction Sensitises Myeloma Cells to Bortezomib-Induced Apoptosis and Alleviates Tumour Microenvironment-Mediated Cell Resistance.

Caillot, Mélody; Zylbersztejn, Florence; Maitre, Elsa; Bourgeais, Jérôme; Hérault, Olivier; Sola, Brigitte

Caillot, Mélody; Zylbersztejn, Florence; Maitre, Elsa; Bourgeais, Jérôme; Hérault, Olivier; Sola, Brigitte.

Affiliation

Caillot M; INSERM, UNICAEN, Normandie Univ, F-14000 Caen, France.
Zylbersztejn F; INSERM, UNICAEN, Normandie Univ, F-14000 Caen, France.
Maitre E; INSERM, UNICAEN, Normandie Univ, F-14000 Caen, France.
Bourgeais J; Laboratoire d'Hématologie, CHU Côte de Nacre, F-14000 Caen, France.
Hérault O; Service d'Hématologie Biologique, CHRU de Tours, F-37000 Tours, France.
Sola B; Service d'Hématologie Biologique, CHRU de Tours, F-37000 Tours, France.

Cells ; 9(11)2020 10 26.

Article in En | MEDLINE | ID: mdl-33114738

Subject(s)

Apoptosis/drug effects; Bortezomib/pharmacology; Drug Resistance, Neoplasm; Multiple Myeloma/metabolism; Multiple Myeloma/pathology; Reactive Oxygen Species/metabolism; Tumor Microenvironment/drug effects; Autophagy/drug effects; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Synergism; Humans; Multiple Myeloma/drug therapy; Multiple Myeloma/etiology; Oxidation-Reduction; Signal Transduction/drug effects

Key words

3-D culture; antioxidant enzymes; auranofin; bortezomib; reactive oxygen species; resistance; survival

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Reactive Oxygen Species / Apoptosis / Drug Resistance, Neoplasm / Tumor Microenvironment / Bortezomib / Multiple Myeloma Type of study: Etiology_studies Limits: Humans Language: En Journal: Cells Year: 2020 Document type: Article Affiliation country: France

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