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Design and synthesis of novel 4-substituted quinazoline-2-carboxamide derivatives targeting AcrB to reverse the bacterial multidrug resistance.
Gu, Xinjie; Pisoni, Lily A; Wang, Yinhu; Song, Di; Sykes, Matthew J; Qin, Yinhui; Semple, Susan J; Polyak, Steven W; Venter, Henrietta; Ma, Shutao.
Affiliation
  • Gu X; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 West Wenhua Road, Jinan 250012, China.
  • Pisoni LA; Health and Biomedical Innovation, Clinical and Health Sciences, University of South Australia, Adelaide, SA 5000, Australia.
  • Wang Y; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 West Wenhua Road, Jinan 250012, China; School of Pharmacy, Liaocheng University, Liaocheng, China.
  • Song D; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 West Wenhua Road, Jinan 250012, China.
  • Sykes MJ; Health and Biomedical Innovation, Clinical and Health Sciences, University of South Australia, Adelaide, SA 5000, Australia.
  • Qin Y; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 West Wenhua Road, Jinan 250012, China.
  • Semple SJ; Health and Biomedical Innovation, Clinical and Health Sciences, University of South Australia, Adelaide, SA 5000, Australia.
  • Polyak SW; Health and Biomedical Innovation, Clinical and Health Sciences, University of South Australia, Adelaide, SA 5000, Australia.
  • Venter H; Health and Biomedical Innovation, Clinical and Health Sciences, University of South Australia, Adelaide, SA 5000, Australia. Electronic address: rietie.venter@unisa.edu.au.
  • Ma S; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 West Wenhua Road, Jinan 250012, China. Electronic address: mashutao@sdu.edu.cn.
Bioorg Chem ; 105: 104394, 2020 12.
Article in En | MEDLINE | ID: mdl-33120321
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Quinazolines / Drug Design / Escherichia coli Proteins / Multidrug Resistance-Associated Proteins / Drug Resistance, Multiple, Bacterial / Escherichia coli / Anti-Bacterial Agents Type of study: Prognostic_studies Limits: Humans Language: En Journal: Bioorg Chem Year: 2020 Document type: Article Affiliation country: China
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Quinazolines / Drug Design / Escherichia coli Proteins / Multidrug Resistance-Associated Proteins / Drug Resistance, Multiple, Bacterial / Escherichia coli / Anti-Bacterial Agents Type of study: Prognostic_studies Limits: Humans Language: En Journal: Bioorg Chem Year: 2020 Document type: Article Affiliation country: China