Renal Reabsorptive Transport of Uric Acid Precursor Xanthine by URAT1 and GLUT9.

Arakawa, Hiroshi; Amezawa, Natsumi; Kawakatsu, Yu; Tamai, Ikumi

Arakawa, Hiroshi; Amezawa, Natsumi; Kawakatsu, Yu; Tamai, Ikumi.

Affiliation

Arakawa H; Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University.
Amezawa N; Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University.
Kawakatsu Y; Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University.
Tamai I; Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University.

Biol Pharm Bull ; 43(11): 1792-1798, 2020.

Article in En | MEDLINE | ID: mdl-33132325

Subject(s)

Anion Transport Proteins/metabolism; Glucose Transport Proteins, Facilitative/metabolism; Monosaccharide Transport Proteins/metabolism; Organic Anion Transporters/metabolism; Organic Cation Transport Proteins/metabolism; Xanthine/pharmacokinetics; Animals; Anion Transport Proteins/antagonists & inhibitors; Benzothiazoles/administration & dosage; Dogs; Glucose Transport Proteins, Facilitative/genetics; Kidney Tubules, Proximal/drug effects; Kidney Tubules, Proximal/metabolism; Madin Darby Canine Kidney Cells; Models, Animal; Nitriles/administration & dosage; Oocytes; Organic Anion Transporters/genetics; Organic Cation Transport Proteins/genetics; Pyridines/administration & dosage; Rats; Rats, Wistar; Reactive Oxygen Species; Recombinant Proteins/genetics; Recombinant Proteins/metabolism; Renal Elimination/drug effects; Uric Acid/metabolism; Xanthine/blood; Xanthine/metabolism; Xanthine/urine; Xanthine Dehydrogenase/antagonists & inhibitors; Xanthine Dehydrogenase/metabolism; Xenopus laevis

Key words

kidney; uric acid; uric acid reabsorptive transporter; xanthine; xanthine oxidoreductase

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Monosaccharide Transport Proteins / Xanthine / Anion Transport Proteins / Organic Anion Transporters / Organic Cation Transport Proteins / Glucose Transport Proteins, Facilitative Limits: Animals Language: En Journal: Biol Pharm Bull Journal subject: BIOQUIMICA / FARMACOLOGIA Year: 2020 Document type: Article Country of publication: Japan

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