Oxidative stress antagonizes fluoroquinolone drug sensitivity via the SoxR-SUF Fe-S cluster homeostatic axis.

Gerstel, Audrey; Zamarreño Beas, Jordi; Duverger, Yohann; Bouveret, Emmanuelle; Barras, Frédéric; Py, Béatrice

Gerstel, Audrey; Zamarreño Beas, Jordi; Duverger, Yohann; Bouveret, Emmanuelle; Barras, Frédéric; Py, Béatrice.

Affiliation

Gerstel A; Laboratoire de Chimie Bactérienne, Aix-Marseille Université-CNRS UMR7283, Institut de Microbiologie de la Méditerranée, Marseille, France.
Zamarreño Beas J; Laboratoire de Chimie Bactérienne, Aix-Marseille Université-CNRS UMR7283, Institut de Microbiologie de la Méditerranée, Marseille, France.
Duverger Y; Laboratoire de Chimie Bactérienne, Aix-Marseille Université-CNRS UMR7283, Institut de Microbiologie de la Méditerranée, Marseille, France.
Bouveret E; SAMe Unit, Département de Microbiologie, Institut Pasteur, CNRS UMR IMM 2001, Paris, France.
Barras F; Laboratoire de Chimie Bactérienne, Aix-Marseille Université-CNRS UMR7283, Institut de Microbiologie de la Méditerranée, Marseille, France.
Py B; SAMe Unit, Département de Microbiologie, Institut Pasteur, CNRS UMR IMM 2001, Paris, France.

PLoS Genet ; 16(11): e1009198, 2020 11.

Article in En | MEDLINE | ID: mdl-33137124

Subject(s)

Anti-Bacterial Agents/pharmacology; Bacterial Proteins/metabolism; Drug Resistance, Bacterial/genetics; Escherichia coli/physiology; Iron-Sulfur Proteins/metabolism; Transcription Factors/metabolism; Anti-Bacterial Agents/therapeutic use; Carrier Proteins/genetics; Carrier Proteins/metabolism; Drug Antagonism; Drug Resistance, Bacterial/drug effects; Escherichia coli/drug effects; Escherichia coli Infections/drug therapy; Escherichia coli Infections/microbiology; Escherichia coli Proteins/genetics; Escherichia coli Proteins/metabolism; Gene Expression Regulation, Bacterial; Humans; Methylphenazonium Methosulfate/pharmacology; Microbial Sensitivity Tests; Norfloxacin/pharmacology; Oxidative Stress/drug effects; Oxidative Stress/genetics

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bacterial Proteins / Transcription Factors / Drug Resistance, Bacterial / Escherichia coli / Iron-Sulfur Proteins / Anti-Bacterial Agents Type of study: Diagnostic_studies Limits: Humans Language: En Journal: PLoS Genet Journal subject: GENETICA Year: 2020 Document type: Article Affiliation country: France Country of publication: United States

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google