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Lipid deposition and metaflammation in diabetic kidney disease.
Mitrofanova, Alla; Fontanella, Antonio M; Merscher, Sandra; Fornoni, Alessia.
Affiliation
  • Mitrofanova A; Katz Family Division of Nephrology and Hypertension, Department of Medicine, University of Miami, Miller School of Medicine, Miami, FL, USA; Peggy and Harold Katz Family Drug Discovery Center, University of Miami, Miller School of Medicine, Miami, FL, USA; Department of Surgery, University of Miami,
  • Fontanella AM; Katz Family Division of Nephrology and Hypertension, Department of Medicine, University of Miami, Miller School of Medicine, Miami, FL, USA; Peggy and Harold Katz Family Drug Discovery Center, University of Miami, Miller School of Medicine, Miami, FL, USA.
  • Merscher S; Katz Family Division of Nephrology and Hypertension, Department of Medicine, University of Miami, Miller School of Medicine, Miami, FL, USA; Peggy and Harold Katz Family Drug Discovery Center, University of Miami, Miller School of Medicine, Miami, FL, USA.
  • Fornoni A; Katz Family Division of Nephrology and Hypertension, Department of Medicine, University of Miami, Miller School of Medicine, Miami, FL, USA; Peggy and Harold Katz Family Drug Discovery Center, University of Miami, Miller School of Medicine, Miami, FL, USA. Electronic address: afornoni@miami.edu.
Curr Opin Pharmacol ; 55: 60-72, 2020 12.
Article in En | MEDLINE | ID: mdl-33137677
ABSTRACT
A critical link between metabolic disorders and a form of low-grade systemic and chronic inflammation has been recently established and named 'Metaflammation'. Metaflammation has been recognized as a key mediator of both microvascular and macrovascular complications of diabetes and as a significant contributor to the development of diabetic kidney disease (DKD). The goal of this review is to summarize the contribution of diabetes-induced inflammation and the related signaling pathways to diabetic complications, with a particular focus on how innate immunity and lipid metabolism influence each other.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Diabetic Nephropathies / Lipid Metabolism / Inflammation Limits: Animals / Humans Language: En Journal: Curr Opin Pharmacol Journal subject: FARMACOLOGIA Year: 2020 Document type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Diabetic Nephropathies / Lipid Metabolism / Inflammation Limits: Animals / Humans Language: En Journal: Curr Opin Pharmacol Journal subject: FARMACOLOGIA Year: 2020 Document type: Article