The utility of a random growth hormone level in determining neonatal growth hormone sufficiency.
Clin Endocrinol (Oxf)
; 94(3): 392-398, 2021 03.
Article
in En
| MEDLINE
| ID: mdl-33140844
ABSTRACT
BACKGROUND:
Random growth hormone (GH) levels have been used in the neonate to investigate congenital growth hormone deficiency (GHD). The cut-off value for use in this diagnosis is yet to be established.METHODS:
This is a retrospective chart review of all random GH levels obtained in neonates ≤28 days of age. Neonates were divided into three groups those diagnosed with congenital GHD, those at risk for GHD (ARF-GHD) and a non-growth hormone deficient (non-GHD) group. Mean GH levels for each group were compared, and ROC analysis was used to identify a cut-off for the diagnosis of GHD.RESULTS:
The study included 138 neonates with the mean age of 9.07 ± 6.6 days, and 65% of these were born at term gestation. Mean GH levels were lower in the GHD group (2.73 ± 1.19 ng/ml) as compared to the ARF-GHD (9.4 ± 7.96 ng/ml, p = .002) and non-GHD groups (14.86 ± 14.42 ng/ml, p = .027). GH values were not significantly different between non-GHD and ARF-GHD groups. ROC analysis identified a cut-off of serum random GH level of 4.5 ng/ml that achieved 100% sensitivity and 83% specificity for the diagnosis of congenital GHD.CONCLUSION:
This study demonstrates that random GH levels obtained in the first 28 days of life can be useful in diagnosing congenital GHD. Moreover, a diagnostic cut-off for congenital GHD using random GH levels was identified.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Human Growth Hormone
/
Dwarfism, Pituitary
Type of study:
Observational_studies
/
Risk_factors_studies
Limits:
Female
/
Humans
/
Newborn
/
Pregnancy
Language:
En
Journal:
Clin Endocrinol (Oxf)
Year:
2021
Document type:
Article
Affiliation country:
United States