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Two new compounds from a mangrove sediment-derived fungus Penicillium polonicum H175.
Liu, Shun-Zhi; Tang, Xi-Xiang; He, Feng-Ming; Jia, Jian-Xin; Hu, Hang; Xie, Bao-Ying; Li, Ming-Yu; Qiu, Ying-Kun.
Affiliation
  • Liu SZ; Fujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences, Xiamen University, Xiamen, China.
  • Tang XX; Key Laboratory of Marine Biogenetic Resources, Third Institute of Oceanography, Ministry of Natural Resources, Xiamen, China.
  • He FM; Fujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences, Xiamen University, Xiamen, China.
  • Jia JX; Fujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences, Xiamen University, Xiamen, China.
  • Hu H; Fujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences, Xiamen University, Xiamen, China.
  • Xie BY; School of Medicine, Xiamen University, Xiamen, China.
  • Li MY; Fujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences, Xiamen University, Xiamen, China.
  • Qiu YK; Fujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences, Xiamen University, Xiamen, China.
Nat Prod Res ; 36(9): 2370-2378, 2022 May.
Article in En | MEDLINE | ID: mdl-33146025
ABSTRACT
Two new compounds, 6-acetyl-4-methoxy-3,5-dimethyl-2H-pyran-2-one (1) and (2E,4E)-5-((2S,3S,4R,5R)-3,4-dihydroxy-2,4,5-trimethyltetrahydrofuran-2-yl)-2,4-dimethylpenta-2,4-dienal (2), and 22 known compounds were identified from the mangrove-forest-derived fungus Penicillium polonicum H175. The structures of these compounds were elucidated by analysis of the high-resolution electrospray ionisation mass spectroscopy (HR-ESI-MS), 1 D and 2 D nuclear magnetic resonance (NMR) data. The hypoglycaemic effect of compounds was evaluated by the Tg (Ins htBidTE-ON; LR) zebrafish model. Compound 3 (aspterric acid) exhibited a significant hypoglycaemic effect equivalent to the positive drug rosiglitazone (RSG) at 10 µmol/L.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Penicillium / Zebrafish Limits: Animals Language: En Journal: Nat Prod Res Year: 2022 Document type: Article Affiliation country: China
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Penicillium / Zebrafish Limits: Animals Language: En Journal: Nat Prod Res Year: 2022 Document type: Article Affiliation country: China