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IFITM3 functions as a PIP3 scaffold to amplify PI3K signalling in B cells.
Lee, Jaewoong; Robinson, Mark E; Ma, Ning; Artadji, Dewan; Ahmed, Mohamed A; Xiao, Gang; Sadras, Teresa; Deb, Gauri; Winchester, Janet; Cosgun, Kadriye Nehir; Geng, Huimin; Chan, Lai N; Kume, Kohei; Miettinen, Teemu P; Zhang, Ye; Nix, Matthew A; Klemm, Lars; Chen, Chun Wei; Chen, Jianjun; Khairnar, Vishal; Wiita, Arun P; Thomas-Tikhonenko, Andrei; Farzan, Michael; Jung, Jae U; Weinstock, David M; Manalis, Scott R; Diamond, Michael S; Vaidehi, Nagarajan; Müschen, Markus.
Affiliation
  • Lee J; Center of Molecular and Cellular Oncology, Yale Cancer Center, Yale School of Medicine, New Haven, CT, USA.
  • Robinson ME; Center of Molecular and Cellular Oncology, Yale Cancer Center, Yale School of Medicine, New Haven, CT, USA.
  • Ma N; Department of Computational and Quantitative Medicine, City of Hope Comprehensive Cancer Center, Duarte, CA, USA.
  • Artadji D; Center of Molecular and Cellular Oncology, Yale Cancer Center, Yale School of Medicine, New Haven, CT, USA.
  • Ahmed MA; Department of Systems Biology, City of Hope Comprehensive Cancer Center, Duarte, CA, USA.
  • Xiao G; Department of Systems Biology, City of Hope Comprehensive Cancer Center, Duarte, CA, USA.
  • Sadras T; Center of Molecular and Cellular Oncology, Yale Cancer Center, Yale School of Medicine, New Haven, CT, USA.
  • Deb G; Department of Systems Biology, City of Hope Comprehensive Cancer Center, Duarte, CA, USA.
  • Winchester J; Department of Systems Biology, City of Hope Comprehensive Cancer Center, Duarte, CA, USA.
  • Cosgun KN; Center of Molecular and Cellular Oncology, Yale Cancer Center, Yale School of Medicine, New Haven, CT, USA.
  • Geng H; Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA, USA.
  • Chan LN; Center of Molecular and Cellular Oncology, Yale Cancer Center, Yale School of Medicine, New Haven, CT, USA.
  • Kume K; Center of Molecular and Cellular Oncology, Yale Cancer Center, Yale School of Medicine, New Haven, CT, USA.
  • Miettinen TP; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Zhang Y; Medical Research Council Laboratory for Molecular Cell Biology, University College London, London, UK.
  • Nix MA; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Klemm L; Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA, USA.
  • Chen CW; Center of Molecular and Cellular Oncology, Yale Cancer Center, Yale School of Medicine, New Haven, CT, USA.
  • Chen J; Department of Systems Biology, City of Hope Comprehensive Cancer Center, Duarte, CA, USA.
  • Khairnar V; Department of Systems Biology, City of Hope Comprehensive Cancer Center, Duarte, CA, USA.
  • Wiita AP; Department of Systems Biology, City of Hope Comprehensive Cancer Center, Duarte, CA, USA.
  • Thomas-Tikhonenko A; Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA, USA.
  • Farzan M; Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia and Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Jung JU; Department of Immunology and Microbiology, The Scripps Research Institute, Jupiter, FL, USA.
  • Weinstock DM; Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
  • Manalis SR; Dana Farber Cancer Institute, Boston, MA, USA.
  • Diamond MS; Harvard Medical School, Boston, MA, USA.
  • Vaidehi N; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Müschen M; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
Nature ; 588(7838): 491-497, 2020 12.
Article in En | MEDLINE | ID: mdl-33149299
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: B-Lymphocytes / Signal Transduction / RNA-Binding Proteins / Phosphatidylinositol Phosphates / Phosphatidylinositol 3-Kinases / Membrane Proteins Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: Nature Year: 2020 Document type: Article Affiliation country: United States Country of publication: United kingdom
Fulltext
Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: B-Lymphocytes / Signal Transduction / RNA-Binding Proteins / Phosphatidylinositol Phosphates / Phosphatidylinositol 3-Kinases / Membrane Proteins Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: Nature Year: 2020 Document type: Article Affiliation country: United States Country of publication: United kingdom