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Efficacy and Safety of Early Initiation of Eplerenone Treatment in Patients with Acute Heart Failure (EARLIER trial): a multicentre, randomized, double-blind, placebo-controlled trial.
Asakura, Masanori; Ito, Shin; Yamada, Takahisa; Saito, Yoshihiko; Kimura, Kazuo; Yamashina, Akira; Hirayama, Atsushi; Kobayashi, Youichi; Hanatani, Akihisa; Tsujimoto, Mitsuru; Yasuda, Satoshi; Abe, Yukio; Higashino, Yorihiko; Tamaki, Yodo; Sugino, Hiroshi; Niinuma, Hiroyuki; Okuhara, Yoshitaka; Koitabashi, Toshimi; Momomura, Shin-Ichi; Asai, Kuniya; Nomura, Akihiro; Kawai, Hiroya; Satoh, Yasuhiro; Yoshikawa, Tsutomu; Hirata, Ken-Ichi; Yokoi, Yoshiaki; Tanaka, Jun; Shibata, Yoshisato; Maejima, Yasuhiro; Tamaki, Shunsuke; Kawata, Hiroyuki; Iwahashi, Noriaki; Kobayashi, Masatake; Higuchi, Yoshiharu; Kada, Akiko; Yamamoto, Haruko; Kitakaze, Masafumi.
Affiliation
  • Asakura M; Department of Cardiovascular and Renal Medicine, Hyogo College of Medicine, Hyogo, Japan.
  • Ito S; Department of Clinical Medicine and Development, National Cerebral and Cardiovascular Center, Osaka, Japan.
  • Yamada T; Department of Clinical Medicine and Development, National Cerebral and Cardiovascular Center, Osaka, Japan.
  • Saito Y; Division of Cardiology, Osaka General Medical Center, Osaka, Japan.
  • Kimura K; Department of Cardiovascular Medicine, Nara Medical University, Nara Medical University Hospital, Nara, Japan.
  • Yamashina A; Division of Cardiology, Yokohama City University Medical Center, Yokohama, Japan.
  • Hirayama A; Department of Cardiology, Tokyo Medical University, Tokyo, Japan.
  • Kobayashi Y; The Division of Cardiology, Department of Medicine, Nihon University Itabashi Hospital, Tokyo, Japan.
  • Hanatani A; Division of Cardiology, Department of Medicine, Showa University Hospital, Tokyo, Japan.
  • Tsujimoto M; Department of Cardiovascular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan.
  • Yasuda S; Department of Cardiology, Cardiovascular Center, Veritas Hospital, Hyogo, Japan.
  • Abe Y; Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Osaka, Japan.
  • Higashino Y; Department of Cardiology, Osaka City General Hospital, Osaka, Japan.
  • Tamaki Y; Department of Cardiology, Higashi Takarazuka Satoh Hospital, Hyogo, Japan.
  • Sugino H; Department of Cardiology, Tenri Hospital, Nara, Tenri, Japan.
  • Niinuma H; Department of Cardiac Surgery, National Hospital Organization Kure Medical Center and Chugoku Cancer Center, Hiroshima, Japan.
  • Okuhara Y; Department of Cardiology, St. Luke's International Hospital, Tokyo, Japan.
  • Koitabashi T; Department of Cardiovascular and Renal Medicine, Hyogo College of Medicine, Hyogo, Japan.
  • Momomura SI; Department of Cardiovascular Medicine, Kitasato University School of Medicine, Tokyo, Japan.
  • Asai K; Cardiovascular Division, Jichi Medical University Saitama Medical Center, Saitama, Japan.
  • Nomura A; Department of Cardiovascular Medicine, Nippon Medical School Chiba Hokusoh Hospital, Chiba, Japan.
  • Kawai H; Department of Cardiovascular and Internal Medicine, Kanazawa University Graduate School of Medical Science, Ishikawa, Japan.
  • Satoh Y; Division of Cardiovascular Medicine, Hyogo Prefectural Himeji Cardiovascular Center, Hyogo Brain and Heart Center, Hyogo, Japan.
  • Yoshikawa T; Department of Cardiology, National Hospital Organization Disaster Medical Center, Tokyo, Japan.
  • Hirata KI; Department of Cardiology, Sakakibara Heart Institute, Tokyo, Japan.
  • Yokoi Y; Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
  • Tanaka J; Department of Medicine, Cardiac Arrhythmia Center, Kishiwada Tokushukai Hospital, Kishiwada, Osaka, Japan.
  • Shibata Y; Department of Cardiology, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Tokyo, Japan.
  • Maejima Y; Department of Cardiology, Miyazaki Medical Association Hospital, Miyazaki, Japan.
  • Tamaki S; Department of Cardiovascular Medicine, Tokyo Medical and Dental University Medical Hospital, Tokyo, Japan.
  • Kawata H; Division of Cardiology, Osaka General Medical Center, Osaka, Japan.
  • Iwahashi N; Department of Cardiovascular Medicine, Nara Medical University, Nara Medical University Hospital, Nara, Japan.
  • Kobayashi M; Division of Cardiology, Yokohama City University Medical Center, Yokohama, Japan.
  • Higuchi Y; Department of Cardiology, Tokyo Medical University, Tokyo, Japan.
  • Kada A; The Division of Cardiology, Department of Medicine, Nihon University Itabashi Hospital, Tokyo, Japan.
  • Yamamoto H; Department of Clinical Research Management, National Hospital Organization Nagoya Medical Center, Aichi, Japan.
  • Kitakaze M; Department of Advance Medical Technology Development, National Cerebral and Cardiovascular Center, 6-1 Kishibeshinmachi Suita 564-8565, Osaka, Japan.
Eur Heart J Cardiovasc Pharmacother ; 8(2): 108-117, 2022 02 16.
Article in En | MEDLINE | ID: mdl-33175088
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Spironolactone / Heart Failure Type of study: Clinical_trials / Diagnostic_studies Limits: Aged / Female / Humans / Male Language: En Journal: Eur Heart J Cardiovasc Pharmacother Year: 2022 Document type: Article Affiliation country: Japan Country of publication: United kingdom
Fulltext
Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Spironolactone / Heart Failure Type of study: Clinical_trials / Diagnostic_studies Limits: Aged / Female / Humans / Male Language: En Journal: Eur Heart J Cardiovasc Pharmacother Year: 2022 Document type: Article Affiliation country: Japan Country of publication: United kingdom