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Self-reporting heavy atom-free photodynamic therapy agents.
Turkoglu, Gulsen; Kayadibi Koygun, Gozde; Yurt, Mediha Nur Zafer; Demirok, Naime; Erbas-Cakmak, Sundus.
Affiliation
  • Turkoglu G; Research and Development Center for Diagnostic Kits (KIT-ARGEM) Konya Food and Agriculture University, 42080, Konya, Turkey and Konya Food and Agriculture University, Department of Molecular Biology and Genetics, 42080, Konya, Turkey. sundus.erbascakmak@gidatarim.edu.tr.
  • Kayadibi Koygun G; Selçuk University, Department of Nanotechnology and Advanced Materials, 42250, Konya, Turkey.
  • Yurt MNZ; Research and Development Center for Diagnostic Kits (KIT-ARGEM) Konya Food and Agriculture University, 42080, Konya, Turkey.
  • Demirok N; Üsküdar University, Department of Molecular Biology and Genetics, 34662, Istanbul, Turkey.
  • Erbas-Cakmak S; Research and Development Center for Diagnostic Kits (KIT-ARGEM) Konya Food and Agriculture University, 42080, Konya, Turkey and Konya Food and Agriculture University, Department of Molecular Biology and Genetics, 42080, Konya, Turkey. sundus.erbascakmak@gidatarim.edu.tr.
Org Biomol Chem ; 18(46): 9433-9437, 2020 12 07.
Article in En | MEDLINE | ID: mdl-33184621
ABSTRACT
Two novel, self-reporting distyryl BODIPY-based photodynamic therapy agents functionalized with singlet oxygen responsive imidazole and tertiary amine moieties are developed. Heavy atom-free photosensitizers are demonstrated to have efficient photodynamic action in MCF7 cells. The fluorescence intensity of the photosensitizers is shown to be reduced as a result of 1O2 generation without any significant change in photodynamic activity.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Photochemotherapy Language: En Journal: Org Biomol Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2020 Document type: Article Affiliation country: Turkey
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Photochemotherapy Language: En Journal: Org Biomol Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2020 Document type: Article Affiliation country: Turkey