The ubiquitin ligase RNF8 regulates Rho GTPases and promotes cytoskeletal changes and motility in triple-negative breast cancer cells.

Pereira De Carvalho, Bruno; Chern, Yi-Jye; He, Jiabei; Chan, Chia-Hsin

Pereira De Carvalho, Bruno; Chern, Yi-Jye; He, Jiabei; Chan, Chia-Hsin.

Affiliation

Pereira De Carvalho B; Department of Pharmacological Sciences, Stony Brook University, NY, USA.
Chern YJ; Department of Pharmacological Sciences, Stony Brook University, NY, USA.
He J; Department of Pharmacological Sciences, Stony Brook University, NY, USA.
Chan CH; Department of Pharmacological Sciences, Stony Brook University, NY, USA.

FEBS Lett ; 595(2): 241-252, 2021 01.

Article in En | MEDLINE | ID: mdl-33205415

Subject(s)

DNA-Binding Proteins/metabolism; Triple Negative Breast Neoplasms/metabolism; Ubiquitin-Protein Ligases/metabolism; cdc42 GTP-Binding Protein/genetics; rhoA GTP-Binding Protein/genetics; Cell Line, Tumor; DNA-Binding Proteins/genetics; Focal Adhesions/metabolism; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; HeLa Cells; Humans; Proteolysis; Pseudopodia/metabolism; Triple Negative Breast Neoplasms/genetics; Ubiquitin-Protein Ligases/genetics; cdc42 GTP-Binding Protein/metabolism; rhoA GTP-Binding Protein/metabolism

Key words

CDC42; RHOA; RNF8; cell migration; cytoskeleton rearrangements; filopodia; focal adhesion; triple-negative breast cancer

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cdc42 GTP-Binding Protein / RhoA GTP-Binding Protein / Ubiquitin-Protein Ligases / DNA-Binding Proteins / Triple Negative Breast Neoplasms Limits: Humans Language: En Journal: FEBS Lett Year: 2021 Document type: Article Affiliation country: United States Country of publication: United kingdom

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