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Fine needle aspiration of salivary gland carcinomas with high-grade transformation: A multi-institutional study of 22 cases and review of the literature.
Nakaguro, Masato; Faquin, William C; Baloch, Zubair W; Cantley, Richard L; Compton, Margaret L; Ely, Kim A; Holmes, Brittany J; Hu, Rong; Kerr, Darcy A; Montone, Kathleen T; Nishino, Michiya; Pantanowitz, Liron; Rossi, Esther Diana; Sadow, Peter M.
Affiliation
  • Nakaguro M; Departments of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
  • Faquin WC; Departments of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
  • Baloch ZW; Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania.
  • Cantley RL; Department of Pathology, The University of Michigan-Michigan Medicine, Ann Arbor, Michigan.
  • Compton ML; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee.
  • Ely KA; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee.
  • Holmes BJ; Department of Pathology, Stanford University School of Medicine, Stanford, California.
  • Hu R; Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
  • Kerr DA; Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire.
  • Montone KT; Geisel School of Medicine at Dartmouth, Dartmouth College, Hanover, New Hampshire.
  • Nishino M; Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania.
  • Pantanowitz L; Departments of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts.
  • Rossi ED; Department of Pathology, The University of Michigan-Michigan Medicine, Ann Arbor, Michigan.
  • Sadow PM; Division of Anatomic Pathology and Histology, Agostino Gemelli School of Medicine, Catholic University of the Sacred Heart, Rome, Italy.
Cancer Cytopathol ; 129(4): 318-325, 2021 04.
Article in En | MEDLINE | ID: mdl-33211402
BACKGROUND: High-grade transformation (HGT) is a rare process whereby conventional low- to intermediate-grade salivary gland carcinomas (SGC) transform into high-grade, poorly or undifferentiated malignancies with focal or complete loss of their conventional histomorphologic features. Because tumors with HGT are associated with a worse prognosis than their conventional counterparts, preoperative recognition of HGT may be of benefit for optimal patient management. Using a multi-institutional approach, we describe the largest fine needle aspiration (FNA) cohort of salivary gland carcinomas with HGT. METHODS: The archives of 9 large academic medical centers were searched, and 22 cases of SGC with HGT were identified by surgical excision accompanied by preoperative FNA. Clinical and cytomorphologic features were retrospectively reviewed. RESULTS: The male-to-female ratio was 14:8, and the mean patient age was 60.2 years. The average tumor size was 3.6 cm, and 19 cases were from the parotid gland. Acinic cell carcinoma with HGT was the most common tumor subtype, comprising 12 cases with HGT, followed by adenoid cystic carcinoma, secretory carcinoma, and other subtypes. Eighteen cases were classified as malignant; however, a specific diagnosis of HGT was not made. Sixteen cases contained a high-grade cytologic component, and 7 cases had a mixture of both conventional and high-grade components retrospectively. CONCLUSIONS: SGC with HGT should be considered in the differential diagnosis of a salivary gland aspirate exhibiting high-grade cytomorphologic features. The presence of distinct tumor populations, conventional and high-grade, should prompt consideration of HGT, especially when the conventional component is acinic cell carcinoma or adenoid cystic carcinoma.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Salivary Gland Neoplasms / Biopsy, Fine-Needle Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Language: En Journal: Cancer Cytopathol Year: 2021 Document type: Article Country of publication: United States

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Salivary Gland Neoplasms / Biopsy, Fine-Needle Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Language: En Journal: Cancer Cytopathol Year: 2021 Document type: Article Country of publication: United States