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Engulfment and cell motility 1 (ELMO1) and apolipoprotein A1 (APOA1) as candidate genes for sickle cell nephropathy.
Saraf, Santosh L; Zhang, Xu; Shah, Binal N; Raslan, Rasha; Tayo, Bamidele O; Lash, James P; Franceschini, Nora; Gordeuk, Victor R.
Affiliation
  • Saraf SL; Division of Hematology and Oncology, Department of Medicine, University of Illinois at Chicago, Chicago, IL, USA.
  • Zhang X; Division of Hematology and Oncology, Department of Medicine, University of Illinois at Chicago, Chicago, IL, USA.
  • Shah BN; Division of Hematology and Oncology, Department of Medicine, University of Illinois at Chicago, Chicago, IL, USA.
  • Raslan R; Division of Hematology and Oncology, Department of Medicine, University of Illinois at Chicago, Chicago, IL, USA.
  • Tayo BO; Department of Public Health Sciences, Loyola University Chicago Stritch School of Medicine, Maywood, IL, USA.
  • Lash JP; Division of Nephrology, Department of Medicine, University of Illinois at Chicago, Chicago, IL, USA.
  • Franceschini N; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.
  • Gordeuk VR; Division of Hematology and Oncology, Department of Medicine, University of Illinois at Chicago, Chicago, IL, USA.
Br J Haematol ; 193(3): 628-632, 2021 05.
Article in En | MEDLINE | ID: mdl-33216373
ABSTRACT
Sickle cell disease (SCD) and apolipoprotein L1 (APOL1) G1/G2 variants increase chronic kidney disease (CKD) risk in African Americans by poorly understood mechanisms. We applied bioinformatics to identify new candidate genes associated with SCD-related CKD. An interaction network demonstrated APOA1 connecting haemoglobin subunit ß (HBB) and APOL1 with 36 other candidate genes. Gene expression revealed upregulation of engulfment and cell motility 1 (ELMO1) and downregulation of APOA1 in the kidney cortex of SCD versus non-SCD mice. Analysis of candidate genes identified ELMO1 rs10951509 to be associated with albuminuria and APOA1 rs11216132 with haemoglobinuria in patients with SCD. A bioinformatic approach highlights ELMO1 and APOA1 as potentially associated with SCD nephropathy.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Down-Regulation / Up-Regulation / Cell Movement / Apolipoprotein A-I / Adaptor Proteins, Signal Transducing / Renal Insufficiency, Chronic / Gene Regulatory Networks / Anemia, Sickle Cell Limits: Adult / Animals / Female / Humans / Male Language: En Journal: Br J Haematol Year: 2021 Document type: Article Affiliation country: United States
Fulltext
Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Down-Regulation / Up-Regulation / Cell Movement / Apolipoprotein A-I / Adaptor Proteins, Signal Transducing / Renal Insufficiency, Chronic / Gene Regulatory Networks / Anemia, Sickle Cell Limits: Adult / Animals / Female / Humans / Male Language: En Journal: Br J Haematol Year: 2021 Document type: Article Affiliation country: United States