Photodynamic Inactivation of Bacteria with Porphyrin Derivatives: Effect of Charge, Lipophilicity, ROS Generation, and Cellular Uptake on Their Biological Activity In Vitro.

Sulek, Adam; Pucelik, Barbara; Kobielusz, Marcin; Barzowska, Agata; Dabrowski, Janusz M

Sulek, Adam; Pucelik, Barbara; Kobielusz, Marcin; Barzowska, Agata; Dabrowski, Janusz M.

Affiliation

Sulek A; Faculty of Chemistry, Jagiellonian University, 30-387 Krakow, Poland.
Pucelik B; Malopolska Center of Biotechnology, Jagiellonian University, 30-387 Krakow, Poland.
Kobielusz M; Faculty of Chemistry, Jagiellonian University, 30-387 Krakow, Poland.
Barzowska A; Malopolska Center of Biotechnology, Jagiellonian University, 30-387 Krakow, Poland.
Dabrowski JM; Faculty of Chemistry, Jagiellonian University, 30-387 Krakow, Poland.

Int J Mol Sci ; 21(22)2020 Nov 18.

Article in En | MEDLINE | ID: mdl-33218103

Subject(s)

Bacteria/drug effects; Photosensitizing Agents/pharmacology; Porphyrins/pharmacology; Reactive Oxygen Species/metabolism; Bacteria/metabolism; Bacteria/radiation effects; Drug Resistance, Bacterial/drug effects; Escherichia coli/drug effects; Escherichia coli/metabolism; Escherichia coli/radiation effects; Gram-Negative Bacteria/drug effects; Gram-Negative Bacteria/metabolism; Gram-Negative Bacteria/radiation effects; Gram-Positive Bacteria/drug effects; Gram-Positive Bacteria/metabolism; Gram-Positive Bacteria/radiation effects; Hydrophobic and Hydrophilic Interactions; Light; Microscopy, Electron, Scanning; Molecular Structure; Photochemotherapy/methods; Photosensitizing Agents/chemistry; Porphyrins/chemistry; Species Specificity; Staphylococcus aureus/drug effects; Staphylococcus aureus/metabolism; Staphylococcus aureus/radiation effects

Key words

antimicrobial activity; efflux pumps; multidrug resistance (MDR); photodynamic inactivation (PDI); porphyrins; reactive oxygen species (ROS); singlet oxygen

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Porphyrins / Bacteria / Reactive Oxygen Species / Photosensitizing Agents Language: En Journal: Int J Mol Sci Year: 2020 Document type: Article Affiliation country: Poland Country of publication: Switzerland

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