Window of Opportunity Clinical Trials to Evaluate Novel Therapies for Brain Tumors.
Neurosurg Clin N Am
; 32(1): 93-104, 2021 Jan.
Article
in En
| MEDLINE
| ID: mdl-33223031
ABSTRACT
Despite significant improvement in understanding of molecular underpinnings driving glioblastoma, there is minimal improvement in overall survival of patients. This poor outcome is caused in part by traditional designs of early phase clinical trials, which focus on clinical assessments of drug toxicity and response. Window of opportunity trials overcome this shortcoming by assessing drug-induced on-target molecular alterations in post-treatment human tumor specimens. This article provides an overview of window of opportunity trials, including novel designs for incorporating biologic end points into early stage trials in context of brain tumors, and examples of successfully executed window of opportunity trials for glioblastoma.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Brain Neoplasms
/
Glioblastoma
/
Drug Evaluation
Limits:
Humans
Language:
En
Journal:
Neurosurg Clin N Am
Journal subject:
NEUROCIRURGIA
Year:
2021
Document type:
Article
Affiliation country:
United States