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Two new indole-diterpenoids from the marine-derived fungus Penicillium sp. KFD28.
Chen, Ming-Yang; Xie, Qing-Yi; Kong, Fan-Dong; Ma, Qing-Yun; Zhou, Li-Man; Yuan, Jing-Zhe; Dai, Hao-Fu; Wu, You-Gen; Zhao, You-Xing.
Affiliation
  • Chen MY; College of Horticulture, Hainan University, Haikou 570228, China.
  • Xie QY; Haikou Key Laboratory for Research and Utilization of Tropical Natural Products, Institute of Tropical Bioscience and Biotechnology, CATAS, Haikou 571101, China.
  • Kong FD; Haikou Key Laboratory for Research and Utilization of Tropical Natural Products, Institute of Tropical Bioscience and Biotechnology, CATAS, Haikou 571101, China.
  • Ma QY; Haikou Key Laboratory for Research and Utilization of Tropical Natural Products, Institute of Tropical Bioscience and Biotechnology, CATAS, Haikou 571101, China.
  • Zhou LM; Haikou Key Laboratory for Research and Utilization of Tropical Natural Products, Institute of Tropical Bioscience and Biotechnology, CATAS, Haikou 571101, China.
  • Yuan JZ; Haikou Key Laboratory for Research and Utilization of Tropical Natural Products, Institute of Tropical Bioscience and Biotechnology, CATAS, Haikou 571101, China.
  • Dai HF; Haikou Key Laboratory for Research and Utilization of Tropical Natural Products, Institute of Tropical Bioscience and Biotechnology, CATAS, Haikou 571101, China.
  • Wu YG; Hainan Academy of Tropical Agricultural Resource, CATAS, Haikou 571101, China.
  • Zhao YX; College of Horticulture, Hainan University, Haikou 570228, China.
J Asian Nat Prod Res ; 23(11): 1030-1036, 2021 Nov.
Article in En | MEDLINE | ID: mdl-33225746
ABSTRACT
Two new compounds named epipaxilline (1) and penerpene J (2) were isolated from the marine-derived fungus Penicillium sp. KFD28. Their structures including absolute configurations were determined on the basis of spectroscopic methods and ECD analysis. Compounds 1 and 2 showed inhibitory activities against PTP1B with IC50 values of 31.5 and 9.5 µM, respectively, and compound 2 also showed inhibitory activities against TCPTP with IC50 value of 14.7 µM.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Penicillium / Diterpenes Language: En Journal: J Asian Nat Prod Res Journal subject: BOTANICA / QUIMICA Year: 2021 Document type: Article Affiliation country: China
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Penicillium / Diterpenes Language: En Journal: J Asian Nat Prod Res Journal subject: BOTANICA / QUIMICA Year: 2021 Document type: Article Affiliation country: China