Synthetic thick filaments: A new avenue for better understanding the myosin super-relaxed state in healthy, diseased, and mavacamten-treated cardiac systems.

Gollapudi, Sampath K; Yu, Ming; Gan, Qing-Fen; Nag, Suman

Gollapudi, Sampath K; Yu, Ming; Gan, Qing-Fen; Nag, Suman.

Affiliation

Gollapudi SK; Department of Biology, MyoKardia, Inc., Brisbane, California, USA.
Yu M; Department of Biology, MyoKardia, Inc., Brisbane, California, USA.
Gan QF; Department of Biology, MyoKardia, Inc., Brisbane, California, USA.
Nag S; Department of Biology, MyoKardia, Inc., Brisbane, California, USA. Electronic address: snag@myokardia.com.

J Biol Chem ; 296: 100114, 2021.

Article in En | MEDLINE | ID: mdl-33234590

Subject(s)

Benzylamines/chemistry; Benzylamines/metabolism; Myosins/metabolism; Uracil/analogs & derivatives; Adenosine Triphosphate/metabolism; Animals; Humans; Muscle, Skeletal/metabolism; Myocardial Contraction/physiology; Myosin Light Chains/chemistry; Myosin Light Chains/metabolism; Myosin Subfragments/chemistry; Myosin Subfragments/metabolism; Myosins/chemistry; Phosphorylation/physiology; Uracil/chemistry; Uracil/metabolism

Key words

R403Q; Super-Relaxed State (SRX); interacting-heads motif (IHM); mavacamten; synthetic thick filaments (STFs)

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Uracil / Benzylamines / Myosins Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Biol Chem Year: 2021 Document type: Article Affiliation country: United States Country of publication: United States

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