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Replacing the Rhamnose-Xylose Moiety of QS-21 with Simpler Terminal Disaccharide Units Attenuates Adjuvant Activity in Truncated Saponin Variants.
Fuentes, Roberto; Ruiz-de-Angulo, Ane; Sacristán, Nagore; Navo, Claudio Daniel; Jiménez-Osés, Gonzalo; Anguita, Juan; Fernández-Tejada, Alberto.
Affiliation
  • Fuentes R; Chemical Immunology Laboratory, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Biscay Science and Technology Park, Building 801A, 48160, Derio, Spain.
  • Ruiz-de-Angulo A; Chemical Immunology Laboratory, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Biscay Science and Technology Park, Building 801A, 48160, Derio, Spain.
  • Sacristán N; Chemical Immunology Laboratory, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Biscay Science and Technology Park, Building 801A, 48160, Derio, Spain.
  • Navo CD; Computational Chemistry Laboratory, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Biscay Science and Technology Park, Building 801A, 48160, Derio, Spain.
  • Jiménez-Osés G; Computational Chemistry Laboratory, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Biscay Science and Technology Park, Building 801A, 48160, Derio, Spain.
  • Anguita J; Inflammation and Macrophage Plasticity Laboratory, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Biscay Science and Technology Park, Building 801A, 48160, Derio, Spain.
  • Fernández-Tejada A; Ikerbasque, Basque Foundation for Science, Plaza Euskadi 5, 48009, Bilbao, Spain.
Chemistry ; 27(14): 4731-4737, 2021 Mar 08.
Article in En | MEDLINE | ID: mdl-33236801
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Saponins / Adjuvants, Immunologic Limits: Humans Language: En Journal: Chemistry Journal subject: QUIMICA Year: 2021 Document type: Article Affiliation country: Spain Country of publication: Germany
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Saponins / Adjuvants, Immunologic Limits: Humans Language: En Journal: Chemistry Journal subject: QUIMICA Year: 2021 Document type: Article Affiliation country: Spain Country of publication: Germany