%, Percentage; AA, Allergic asthma; AP-1, Activator protein-1; ATO, Atorvastatin; Atorvastatin; BALF, Bronchoalveolar lavage fluid; CCL7, Chemokine ligand 7; CI, Confidence interval; COPD, Chronic obstructive pulmonary disease; CRP, C-reactive protein; CS, Cigarettes smoke; CYP3A4/5, Cytochrome Metabolic enzymes3A4/5; FPP, Farnesylpyrophosphate; G, Gram; GEF, Guanine nucleotide exchange factors; GGPP, Geranylgeranylpyrophosphate; IL, Interleukins; Inflammation; Inhale; Log P, Partition coefficient; MMPs, Matrix-metalloprotease; MVA, Mevalonic acid; NADPH, Nicotinamide adenine dinucleotide phosphate; NCSCL, Non-small cell lung cancer; NF-κB, Nuclear factor kappa; NOS, Nitric oxide synthase; NaOH, Sodium hydroxide; OATP, Organic anion transporting polypeptide; Oral; Oxidation; PEG, Polyethylene glycol; PPE, Porcine pancreatic elastase; ROS, Reactive oxygen species; Respiratory diseases; SAS, Supercritical antisolvent; SphK1, Sphingosine kinase 1; TGF, Transforming growth factor; TNF-a, Tumour necrosis factor alpha; TSC, Tuberous sclerosis; UDP, Uridine diphosphate; UV, Ultraviolet light; VEGF, Vascular endothelial cell growth factor; VLDL, Very low-density lipoproteins; WHO, World Health Organization; log D, Coefficient values octanol/water; m2, Square meter; mg, Milligram; mg/day, Milligram per day; ml, Millilitres; pH, Measure of the acidity or basicity of an aqueous solution; pKa, Dissociation constant; s, Second; v/v, Volume per volume; °C/min, Temperature in degrees per minutes; µM, Micromolar; µg, Microgram; µg/day, Microgram per day; µg/mL, Microgram per millilitre