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Transcriptomic profiling across the nonalcoholic fatty liver disease spectrum reveals gene signatures for steatohepatitis and fibrosis.
Govaere, Olivier; Cockell, Simon; Tiniakos, Dina; Queen, Rachel; Younes, Ramy; Vacca, Michele; Alexander, Leigh; Ravaioli, Federico; Palmer, Jeremy; Petta, Salvatore; Boursier, Jerome; Rosso, Chiara; Johnson, Katherine; Wonders, Kristy; Day, Christopher P; Ekstedt, Mattias; Oresic, Matej; Darlay, Rebecca; Cordell, Heather J; Marra, Fabio; Vidal-Puig, Antonio; Bedossa, Pierre; Schattenberg, Jörn M; Clément, Karine; Allison, Michael; Bugianesi, Elisabetta; Ratziu, Vlad; Daly, Ann K; Anstee, Quentin M.
Affiliation
  • Govaere O; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
  • Cockell S; Bioinformatics Support Unit, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
  • Tiniakos D; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
  • Queen R; Department of Pathology, Aretaieio Hospital, National and Kapodistrian University of Athens, 15771 Athens, Greece.
  • Younes R; Bioinformatics Support Unit, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
  • Vacca M; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
  • Alexander L; Department of Medical Sciences, Division of Gastro-Hepatology, A.O. Città della Salute e della Scienza di Torino, University of Turin, 10124 Turin, Italy.
  • Ravaioli F; University of Cambridge Metabolic Research Laboratories, Wellcome-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK.
  • Palmer J; SomaLogic Inc., Boulder, CO 80301, USA.
  • Petta S; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
  • Boursier J; Department of Medical and Surgical Sciences, University of Bologna, 40126 Bologna, Italy.
  • Rosso C; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
  • Johnson K; Sezione di Gastroenterologia, Dipartimento Biomedico di Medicina Interna e Specialistica, Università di Palermo, 90133 Palermo, Italy.
  • Wonders K; Hepatology Department, Angers University Hospital, 49933 Angers, France.
  • Day CP; Department of Medical Sciences, Division of Gastro-Hepatology, A.O. Città della Salute e della Scienza di Torino, University of Turin, 10124 Turin, Italy.
  • Ekstedt M; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
  • Oresic M; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
  • Darlay R; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
  • Cordell HJ; Department of Health, Medicine and Caring Sciences, Linköping University, 581 83 Linköping, Sweden.
  • Marra F; School of Medical Sciences, Örebro University, 702 81 Örebro, Sweden.
  • Vidal-Puig A; Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
  • Bedossa P; Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
  • Schattenberg JM; Dipartimento di Medicina Sperimentale e Clinica, University of Florence, 50121 Florence, Italy.
  • Clément K; University of Cambridge Metabolic Research Laboratories, Wellcome-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK.
  • Allison M; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
  • Bugianesi E; Assistance Publique-Hôpitaux de Paris, Hôpital Pitié Salpêtrière, Sorbonne University, ICAN (Institute of Cardiometabolism and Nutrition), 75013 Paris, France.
  • Ratziu V; Department of Medicine, University Hospital Mainz, 55131 Mainz, Germany.
  • Daly AK; Nutrition and Obesities: Systemic Approaches, INSERM, Sorbonne University, 75006 Paris, France.
  • Anstee QM; Liver Unit, Department of Medicine, NIHR Cambridge Biomedical Research Centre, Cambridge University NHS Foundation Trust, Cambridge CB2 0QQ, UK.
Sci Transl Med ; 12(572)2020 12 02.
Article in En | MEDLINE | ID: mdl-33268509
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Diabetes Mellitus, Type 2 / Non-alcoholic Fatty Liver Disease Type of study: Clinical_trials / Prognostic_studies Limits: Humans Language: En Journal: Sci Transl Med Journal subject: CIENCIA / MEDICINA Year: 2020 Document type: Article Affiliation country: United kingdom Country of publication: United States
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Diabetes Mellitus, Type 2 / Non-alcoholic Fatty Liver Disease Type of study: Clinical_trials / Prognostic_studies Limits: Humans Language: En Journal: Sci Transl Med Journal subject: CIENCIA / MEDICINA Year: 2020 Document type: Article Affiliation country: United kingdom Country of publication: United States