Building genomes to understand biology.
Nat Commun
; 11(1): 6177, 2020 12 02.
Article
in En
| MEDLINE
| ID: mdl-33268788
ABSTRACT
Genetic manipulation is one of the central strategies that biologists use to investigate the molecular underpinnings of life and its diversity. Thus, advances in genetic manipulation usually lead to a deeper understanding of biological systems. During the last decade, the construction of chromosomes, known as synthetic genomics, has emerged as a novel approach to genetic manipulation. By facilitating complex modifications to chromosome content and structure, synthetic genomics opens new opportunities for studying biology through genetic manipulation. Here, we discuss different classes of genetic manipulation that are enabled by synthetic genomics, as well as biological problems they each can help solve.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
DNA
/
Genome
/
Chromosomes, Artificial
/
Genomics
/
Synthetic Biology
Limits:
Humans
Language:
En
Journal:
Nat Commun
Journal subject:
BIOLOGIA
/
CIENCIA
Year:
2020
Document type:
Article
Affiliation country:
United States