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Association between SARS-CoV-2 infection and Kawasaki-like multisystem inflammatory syndrome: a retrospective matched case-control study, Paris, France, April to May 2020.
Toubiana, Julie; Levy, Corinne; Allali, Slimane; Jung, Camille; Leruez-Ville, Marianne; Varon, Emmanuelle; Bajolle, Fanny; Ouldali, Naim; Chareyre, Judith; Béchet, Stephane; Elbez, Annie; Casanova, Jean-Laurent; Chalumeau, Martin; Cohen, Robert; Cohen, Jérémie F.
Affiliation
  • Toubiana J; Department of General Pediatrics and Pediatric Infectious Diseases, Necker-Enfants Malades University Hospital, Assistance Publique - Hôpitaux de Paris (AP-HP), Université de Paris, Paris, France.
  • Levy C; Institut Pasteur, Biodiversity and Epidemiology of Bacterial Pathogens, Paris, France.
  • Allali S; ACTIV, Association Clinique et Thérapeutique Infantile du Val-de-Marne, Créteil, France.
  • Jung C; Université Paris Est, IMRB-GRC GEMINI, Créteil, France.
  • Leruez-Ville M; Clinical Research Center (CRC), Centre Hospitalier Intercommunal de Créteil, Créteil, France.
  • Varon E; GPIP, Groupe de Pathologie Infectieuse Pédiatrique, Paris, France.
  • Bajolle F; AFPA, Association Française de Pédiatrie Ambulatoire, Saint-Germain-en-Laye, France.
  • Ouldali N; Department of General Pediatrics and Pediatric Infectious Diseases, Necker-Enfants Malades University Hospital, Assistance Publique - Hôpitaux de Paris (AP-HP), Université de Paris, Paris, France.
  • Chareyre J; Université Paris Est, IMRB-GRC GEMINI, Créteil, France.
  • Béchet S; Clinical Research Center (CRC), Centre Hospitalier Intercommunal de Créteil, Créteil, France.
  • Elbez A; Virology laboratory, Necker-Enfants Malades University Hospital, AP-HP, EA 7328, Université de Paris, Paris, France.
  • Casanova JL; Université Paris Est, IMRB-GRC GEMINI, Créteil, France.
  • Chalumeau M; Clinical Research Center (CRC), Centre Hospitalier Intercommunal de Créteil, Créteil, France.
  • Cohen R; GPIP, Groupe de Pathologie Infectieuse Pédiatrique, Paris, France.
  • Cohen JF; Laboratoire de Microbiologie, Centre Hospitalier Intercommunal de Créteil, Créteil, France.
Euro Surveill ; 25(48)2020 12.
Article in En | MEDLINE | ID: mdl-33272357
ABSTRACT
We assessed the association between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and Kawasaki disease (KD)-like multisystem inflammatory syndrome in a retrospective case-control study in France. RT-PCR and serological tests revealed SARS-CoV-2 infection in 17/23 cases vs 11/102 controls (matched odds ratio 26.4; 95% confidence interval 6.0-116.9), indicating strong association between SARS-CoV-2 infection and KD-like illness. Clinicians should keep a high level of suspicion for KD-like illness during the COVID-19 pandemic.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Coronavirus / Systemic Inflammatory Response Syndrome / COVID-19 / Mucocutaneous Lymph Node Syndrome Type of study: Observational_studies / Risk_factors_studies Limits: Child / Child, preschool / Humans Country/Region as subject: Europa Language: En Journal: Euro Surveill Journal subject: DOENCAS TRANSMISSIVEIS Year: 2020 Document type: Article Affiliation country: France
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Coronavirus / Systemic Inflammatory Response Syndrome / COVID-19 / Mucocutaneous Lymph Node Syndrome Type of study: Observational_studies / Risk_factors_studies Limits: Child / Child, preschool / Humans Country/Region as subject: Europa Language: En Journal: Euro Surveill Journal subject: DOENCAS TRANSMISSIVEIS Year: 2020 Document type: Article Affiliation country: France