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Soluble VCAM-1 promotes gemcitabine resistance via macrophage infiltration and predicts therapeutic response in pancreatic cancer.
Takahashi, Ryota; Ijichi, Hideaki; Sano, Makoto; Miyabayashi, Koji; Mohri, Dai; Kim, Jinsuk; Kimura, Gen; Nakatsuka, Takuma; Fujiwara, Hiroaki; Yamamoto, Keisuke; Kudo, Yotaro; Tanaka, Yasuo; Tateishi, Keisuke; Nakai, Yousuke; Morishita, Yasuyuki; Soma, Katsura; Takeda, Norihiko; Moses, Harold L; Isayama, Hiroyuki; Koike, Kazuhiko.
Affiliation
  • Takahashi R; Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, 113-8655, Japan. rtakahashi-tky@umin.ac.jp.
  • Ijichi H; Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, 113-8655, Japan.
  • Sano M; Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, 113-8655, Japan.
  • Miyabayashi K; Division of Medical Research Planning and Development, Nihon University School of Medicine, Itabashi-ku, Tokyo, 173-8610, Japan.
  • Mohri D; Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, 113-8655, Japan.
  • Kim J; Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, 113-8655, Japan.
  • Kimura G; Division of Medical Research Planning and Development, Nihon University School of Medicine, Itabashi-ku, Tokyo, 173-8610, Japan.
  • Nakatsuka T; Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, 113-8655, Japan.
  • Fujiwara H; Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, 113-8655, Japan.
  • Yamamoto K; Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, 113-8655, Japan.
  • Kudo Y; Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, 113-8655, Japan.
  • Tanaka Y; Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, 113-8655, Japan.
  • Tateishi K; Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, 113-8655, Japan.
  • Nakai Y; Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, 113-8655, Japan.
  • Morishita Y; Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, 113-8655, Japan.
  • Soma K; Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, 113-8655, Japan.
  • Takeda N; Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, 113-8655, Japan.
  • Moses HL; Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, 113-8655, Japan.
  • Isayama H; Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, Tochigi, 329-0498, Japan.
  • Koike K; Vanderbilt-Ingram Comprehensive Cancer Center, Vanderbilt University, 691 Preston Building, Nashville, TN, 37232, USA.
Sci Rep ; 10(1): 21194, 2020 12 03.
Article in En | MEDLINE | ID: mdl-33273652
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pancreatic Neoplasms / Vascular Cell Adhesion Molecule-1 / Drug Resistance, Neoplasm / Deoxycytidine / Macrophages / Antimetabolites, Antineoplastic Type of study: Prognostic_studies / Risk_factors_studies Limits: Animals / Humans Language: En Journal: Sci Rep Year: 2020 Document type: Article Affiliation country: Japan Country of publication: United kingdom
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pancreatic Neoplasms / Vascular Cell Adhesion Molecule-1 / Drug Resistance, Neoplasm / Deoxycytidine / Macrophages / Antimetabolites, Antineoplastic Type of study: Prognostic_studies / Risk_factors_studies Limits: Animals / Humans Language: En Journal: Sci Rep Year: 2020 Document type: Article Affiliation country: Japan Country of publication: United kingdom