Toxicities of axitinib, sunitinib and temsirolimus: implications for progression-free and overall survival in metastatic renal cell cancer.

Uhlig, Annemarie; Uhlig, Johannes; Trojan, Lutz; Woike, Michael; Leitsmann, Marianne; Strauß, Arne

Uhlig, Annemarie; Uhlig, Johannes; Trojan, Lutz; Woike, Michael; Leitsmann, Marianne; Strauß, Arne.

Affiliation

Uhlig A; Department of Urology, University Medical Center Goettingen, Goettingen, 37075, Germany.
Uhlig J; Department of Diagnostic & Interventional Radiology, University Medical Center Goettingen, Goettingen, 37075, Germany.
Trojan L; Department of Radiology & Biomedical Imaging, Section of Interventional Radiology, Yale School of Medicine, New Haven, CT 06510, USA.
Woike M; Department of Urology, University Medical Center Goettingen, Goettingen, 37075, Germany.
Leitsmann M; Pfizer Pharma GmbH, Berlin, 10785, Germany.
Strauß A; Department of Urology, University Medical Center Goettingen, Goettingen, 37075, Germany.

Future Oncol ; 17(1): 45-56, 2021 Jan.

Article in En | MEDLINE | ID: mdl-33275038

Subject(s)

Axitinib/adverse effects; Carcinoma, Renal Cell/therapy; Kidney Neoplasms/therapy; Sirolimus/analogs & derivatives; Sunitinib/adverse effects; Aged; Axitinib/administration & dosage; Carcinoma, Renal Cell/mortality; Chemotherapy, Adjuvant/adverse effects; Chemotherapy, Adjuvant/methods; Disease Progression; Fatigue/chemically induced; Fatigue/epidemiology; Female; Hand-Foot Syndrome/epidemiology; Hand-Foot Syndrome/etiology; Humans; Incidence; Kidney Neoplasms/mortality; Male; Middle Aged; Nephrectomy; Pneumonia/chemically induced; Pneumonia/epidemiology; Prognosis; Progression-Free Survival; Prospective Studies; Protective Factors; Risk Assessment/methods; Risk Assessment/statistics & numerical data; Sirolimus/administration & dosage; Sirolimus/adverse effects; Stomatitis/chemically induced; Stomatitis/epidemiology; Sunitinib/administration & dosage; Thrombocytopenia/chemically induced; Thrombocytopenia/epidemiology

Key words

axitinib; metastatic renal cell cancer; overall survival; progression-free survival; sunitinib; temsirolimus; treatment side effects

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Carcinoma, Renal Cell / Sirolimus / Sunitinib / Axitinib / Kidney Neoplasms Type of study: Clinical_trials / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Language: En Journal: Future Oncol Year: 2021 Document type: Article Affiliation country: Germany

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