The structure of unliganded sterol carrier protein 2 from Yarrowia lipolytica unveils a mechanism for binding site occlusion.

Gianotti, Alejo R; Klinke, Sebastián; Ermácora, Mario R

Gianotti, Alejo R; Klinke, Sebastián; Ermácora, Mario R.

Affiliation

Gianotti AR; Departamento de Ciencia y Tecnología, Universidad Nacional de Quilmes, Argentina; Grupo de Biología Estructural y Biotecnología, IMBICE, CONICET, Universidad Nacional de Quilmes, Argentina.
Klinke S; Fundación Instituto Leloir, IIBBA-CONICET, and Plataforma Argentina de Biología Estructural y Metabolómica PLABEM, Buenos Aires, Argentina.
Ermácora MR; Departamento de Ciencia y Tecnología, Universidad Nacional de Quilmes, Argentina; Grupo de Biología Estructural y Biotecnología, IMBICE, CONICET, Universidad Nacional de Quilmes, Argentina. Electronic address: ermacora@unq.edu.ar.

J Struct Biol ; 213(1): 107675, 2021 03.

Article in En | MEDLINE | ID: mdl-33278583

Subject(s)

Binding Sites/physiology; Carrier Proteins/chemistry; Carrier Proteins/metabolism; Protein Binding/physiology; Yarrowia/metabolism; Ligands; Lipids/chemistry; Protein Domains/physiology

Key words

Lipid-binding protein; Protein binding; Protein conformation; Sterol carrier protein; X-ray crystallography; Yarrowia lipolytica

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein Binding / Binding Sites / Carrier Proteins / Yarrowia Language: En Journal: J Struct Biol Journal subject: BIOLOGIA MOLECULAR Year: 2021 Document type: Article Affiliation country: Argentina Country of publication: United States

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