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Design and structural optimization of novel 2H-benzo[h]chromene derivatives that target AcrB and reverse bacterial multidrug resistance.
Wang, Yinhu; Alenazy, Rawaf; Gu, Xinjie; Polyak, Steven W; Zhang, Panpan; Sykes, Matthew J; Zhang, Na; Venter, Henrietta; Ma, Shutao.
Affiliation
  • Wang Y; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 West Wenhua Road, Jinan, 250012, China; School of Pharmacy, Liaocheng University, Liaocheng, China.
  • Alenazy R; Clinical and Health Sciences, University of South Australia, Adelaide, SA, 5000, Australia; Department of Medical Laboratory, College of Applied Medical Sciences-Shaqra, Shaqra University, 11961, Saudi Arabia.
  • Gu X; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 West Wenhua Road, Jinan, 250012, China.
  • Polyak SW; Clinical and Health Sciences, University of South Australia, Adelaide, SA, 5000, Australia.
  • Zhang P; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 West Wenhua Road, Jinan, 250012, China.
  • Sykes MJ; Clinical and Health Sciences, University of South Australia, Adelaide, SA, 5000, Australia.
  • Zhang N; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 West Wenhua Road, Jinan, 250012, China.
  • Venter H; Clinical and Health Sciences, University of South Australia, Adelaide, SA, 5000, Australia. Electronic address: rietie.venter@unisa.edu.au.
  • Ma S; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 West Wenhua Road, Jinan, 250012, China. Electronic address: mashutao@sdu.edu.cn.
Eur J Med Chem ; 213: 113049, 2021 Mar 05.
Article in En | MEDLINE | ID: mdl-33279291
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Benzopyrans / Escherichia coli Proteins / Multidrug Resistance-Associated Proteins / Escherichia coli / Anti-Bacterial Agents Language: En Journal: Eur J Med Chem Year: 2021 Document type: Article Affiliation country: China
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Benzopyrans / Escherichia coli Proteins / Multidrug Resistance-Associated Proteins / Escherichia coli / Anti-Bacterial Agents Language: En Journal: Eur J Med Chem Year: 2021 Document type: Article Affiliation country: China