High subcutaneous adipose tissue density correlates negatively with survival in patients with hepatocellular carcinoma.
Liver Int
; 41(4): 828-836, 2021 04.
Article
in En
| MEDLINE
| ID: mdl-33280219
ABSTRACT
BACKGROUND & AIMS:
Body composition parameters have been reported to add information, which can lead to tailored treatment and prognostication for oncological patients. Data for patients with hepatocellular carcinoma (HCC) are scarce. We assessed the association between different body composition parameters and overall survival (OS) in two different newly diagnosed HCC populations.METHODS:
The area (cm2 ) and density (Hounsfield Units [HU]) of skeletal muscle (SM) and adipose tissue (subcutaneous [SAT], visceral [VAT] and intermuscular [IMAT]) were measured on computed tomography (CT) scans at the level of the third lumbar vertebra (L3) in two cohorts of patients diagnosed in different HCC stages (Bern, Switzerland n = 187 and Newcastle, United Kingdom n = 216). Univariate and multivariate Cox regressions analyses were used to assess the crude and adjusted association of body composition parameters with OS.RESULTS:
By univariate analysis, in both cohorts, Bern and Newcastle, high SAT density (hazard ratio [HR] 1.35; 1.12-1.62, P < .001 and 1.44; 1.27-1.63, P < .001, respectively) and high VAT density (HR 1.38; 1.1-1.72, P = .005 and HR 1.53; 1.3-1.81, P < .001, respectively) correlated negatively with survival. After model adjustment for potential baseline confounders (gender, age, diabetes, cirrhosis, MELD score, BCLC stage) in a multivariate analysis, SAT density remained associated with mortality in Bern and Newcastle (Bern HR 1.27; 1.04-1.57, P = .022; Newcastle HR 1.23; 1.03-1.48, P = .022) and VAT remained associated with mortality in Bern (HR 1.31; 1.05-1.65, P = .019).CONCLUSIONS:
Based on two HCC cohorts, our data show that high SAT density correlates negatively with OS in HCC patients.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Carcinoma, Hepatocellular
/
Liver Neoplasms
Type of study:
Prognostic_studies
Limits:
Humans
Country/Region as subject:
Europa
Language:
En
Journal:
Liver Int
Journal subject:
GASTROENTEROLOGIA
Year:
2021
Document type:
Article
Affiliation country:
Switzerland
Publication country:
EEUU
/
ESTADOS UNIDOS
/
ESTADOS UNIDOS DA AMERICA
/
EUA
/
UNITED STATES
/
UNITED STATES OF AMERICA
/
US
/
USA