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Overcoming Adaptive Resistance to KRAS and MEK Inhibitors by Co-targeting mTORC1/2 Complexes in Pancreatic Cancer.
Brown, Wells S; McDonald, Paul C; Nemirovsky, Oksana; Awrey, Shannon; Chafe, Shawn C; Schaeffer, David F; Li, Jinyang; Renouf, Daniel J; Stanger, Ben Z; Dedhar, Shoukat.
Affiliation
  • Brown WS; Department of Integrative Oncology, BC Cancer Research Institute, Vancouver, BC V5Z 1L3, Canada.
  • McDonald PC; Department of Integrative Oncology, BC Cancer Research Institute, Vancouver, BC V5Z 1L3, Canada.
  • Nemirovsky O; Department of Integrative Oncology, BC Cancer Research Institute, Vancouver, BC V5Z 1L3, Canada.
  • Awrey S; Department of Integrative Oncology, BC Cancer Research Institute, Vancouver, BC V5Z 1L3, Canada.
  • Chafe SC; Department of Integrative Oncology, BC Cancer Research Institute, Vancouver, BC V5Z 1L3, Canada.
  • Schaeffer DF; Pancreas Centre BC, Vancouver General Hospital, Vancouver, BC V3Z 1M9, Canada.
  • Li J; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC V6T 2B5, Canada.
  • Renouf DJ; Gastroenterology Division, Department of Medicine and Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Stanger BZ; Medical Oncology, BC Cancer Agency, Vancouver, BC V5Z 4E6, Canada.
  • Dedhar S; Gastroenterology Division, Department of Medicine and Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Cell Rep Med ; 1(8): 100131, 2020 11 17.
Article in En | MEDLINE | ID: mdl-33294856
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pancreatic Neoplasms / Proto-Oncogene Proteins p21(ras) / Mitogen-Activated Protein Kinase Kinases / MAP Kinase Signaling System / Mechanistic Target of Rapamycin Complex 1 / Mechanistic Target of Rapamycin Complex 2 Limits: Animals / Female / Humans Language: En Journal: Cell Rep Med Year: 2020 Document type: Article Affiliation country: Canada Country of publication: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pancreatic Neoplasms / Proto-Oncogene Proteins p21(ras) / Mitogen-Activated Protein Kinase Kinases / MAP Kinase Signaling System / Mechanistic Target of Rapamycin Complex 1 / Mechanistic Target of Rapamycin Complex 2 Limits: Animals / Female / Humans Language: En Journal: Cell Rep Med Year: 2020 Document type: Article Affiliation country: Canada Country of publication: United States