Management for lumbar spinal stenosis: Protocol for a network meta-analysis and systematic review.
J Orthop Surg (Hong Kong)
; 28(3): 2309499020975212, 2020.
Article
in En
| MEDLINE
| ID: mdl-33295239
ABSTRACT
INTRODUCTION:
Lumbar spinal stenosis (LSS) is caused by structural changes of the spine, which lead to several severe symptoms, including back pain, leg pain, numbness and tingling in the legs, as well as reduced physical function. However, there is little evidence suggesting whether a patient with LSS should be treated with surgery. If surgery is recommended, which type of surgery benefits the patient most? To answer these questions, we will conduct a network meta-analysis and a systematic review to compare surgical and nonsurgical interventions in terms of efficacy as well as safety in adult patients with LSS. METHODS ANDANALYSIS:
We will search the PubMed, Cochrane library, and EMBASE databases for articles published prior to October 10, 2019. We will search for randomized controlled trials assessing surgical and nonsurgical interventions for adult patients with degenerative LSS without any language restrictions. The primary outcome measures will be pain and disability. The secondary outcomes will include adverse events (number of events or number of people with each type of adverse event), reoperations, complications, blood loss and operation time. We will obtain the full texts of the potentially relevant studies and independently assess them. The quality of evidence will be evaluated according to the Grading of Recommendations Assessment, Development and Evaluation framework. A random-effects network meta-analysis will be performed to analyze all the evidence under the frequentist framework, and the ranking results will be presented. We will generate plots depicting the network geometry using Stata. The network meta-analysis will be performed according to the Bayesian framework. Ethics and dissemination Ethics approval is not required. The research will be published in a peer-reviewed journal.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Spinal Stenosis
/
Disease Management
/
Orthopedic Procedures
/
Network Meta-Analysis
/
Lumbar Vertebrae
Type of study:
Clinical_trials
/
Prognostic_studies
/
Systematic_reviews
Aspects:
Ethics
Limits:
Adult
/
Humans
Language:
En
Journal:
J Orthop Surg (Hong Kong)
Journal subject:
ORTOPEDIA
Year:
2020
Document type:
Article
Affiliation country:
China