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Dopaminergic neuromodulation has no detectable effect on visual-cue induced haemodynamic response function in the visual cortex: A double-blind, placebo-controlled functional magnetic resonance imaging study.
Manoliu, Andrei; Sladky, Ronald; Scherpiet, Sigrid; Jäncke, Lutz; Kirschner, Matthias; Haugg, Amelie; Bolsinger, Julia; Kraehenmann, Rainer; Stämpfli, Philipp; Scharnowski, Frank; Herwig, Uwe; Seifritz, Erich; Brühl, Annette B.
Affiliation
  • Manoliu A; Department of Psychiatry, Psychotherapy and Psychosomatics, University of Zurich, Zurich, Switzerland.
  • Sladky R; Wellcome Centre for Human Neuroimaging, University College London, London, UK.
  • Scherpiet S; Department of Psychiatry, Psychotherapy and Psychosomatics, University of Zurich, Zurich, Switzerland.
  • Jäncke L; Social, Cognitive and Affective Neuroscience (SCAN) Unit, Department of Cognition, Emotion, and Methods in Psychology, Faculty of Psychology, University of Vienna, Vienna, Austria.
  • Kirschner M; Department of Psychiatry, Psychotherapy and Psychosomatics, University of Zurich, Zurich, Switzerland.
  • Haugg A; Psychological Institute, University of Zurich, Zurich, Switzerland.
  • Bolsinger J; Department of Psychiatry, Psychotherapy and Psychosomatics, University of Zurich, Zurich, Switzerland.
  • Kraehenmann R; Montreal Neurological Institute, McGill University, Montreal, Canada.
  • Stämpfli P; Department of Psychiatry, Psychotherapy and Psychosomatics, University of Zurich, Zurich, Switzerland.
  • Scharnowski F; Department of Psychiatry, Psychotherapy and Psychosomatics, University of Zurich, Zurich, Switzerland.
  • Herwig U; Department of Psychiatry, Psychotherapy and Psychosomatics, University of Zurich, Zurich, Switzerland.
  • Seifritz E; Department of Psychiatry, Psychotherapy and Psychosomatics, University of Zurich, Zurich, Switzerland.
  • Brühl AB; Department of Psychiatry, Psychotherapy and Psychosomatics, University of Zurich, Zurich, Switzerland.
J Psychopharmacol ; 35(1): 100-102, 2021 01.
Article in En | MEDLINE | ID: mdl-33307959
ABSTRACT
The aim of this study was to investigate the effect of acute dopamine agonistic and antagonistic manipulation on the visual-cue induced blood oxygen level-dependent signal response in healthy volunteers. Seventeen healthy volunteers in a double-blind placebo-controlled cross-over design received either a dopamine antagonist, agonist or placebo and underwent functional magnetic resonance imaging. Using classical inference and Bayesian statistics, we found no effect of dopaminergic modulation on properties of visual-cue induced blood oxygen level-dependent signals in the visual cortex, particularly on distinct properties of the haemodynamic response function (amplitude, time-to-peak and width). Dopamine-related effects modulating the neurovascular coupling in the visual cortex might be negligible when measured via functional magnetic resonance imaging.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Visual Cortex / Magnetic Resonance Imaging / Dopamine Antagonists / Dopamine Agonists / Hemodynamics Type of study: Clinical_trials Limits: Adult / Female / Humans / Male Language: En Journal: J Psychopharmacol Journal subject: PSICOFARMACOLOGIA Year: 2021 Document type: Article Affiliation country: Switzerland
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Visual Cortex / Magnetic Resonance Imaging / Dopamine Antagonists / Dopamine Agonists / Hemodynamics Type of study: Clinical_trials Limits: Adult / Female / Humans / Male Language: En Journal: J Psychopharmacol Journal subject: PSICOFARMACOLOGIA Year: 2021 Document type: Article Affiliation country: Switzerland