Antidepressant-like effects of albiflorin involved the NO signaling pathway in rats model of chronic restraint stress.
Chin J Nat Med
; 18(11): 872-880, 2020 Nov.
Article
in En
| MEDLINE
| ID: mdl-33308610
ABSTRACT
The depressant-like effects of albiflorin (AF) were studied on stressed chronic restraint stress (CRS) rats. Experimental rats were subjected to immobilization stress for a daily 6 h-restraining in a plastic restrainer for continuous 21 d and were treated with 30 or 15 mg·kg-1 of AF for 21 d. Control rats were maintained in completely non stressed conditions. Behavioral tests and biochemical analysis were applied to investigating a regulatory mechanism of anti-stress of AF. Treatment with AF significantly restored the depressant-like behaviors. Besides, AF increased the levels of 5-hydroxytryptophan (5-HT), 5-hydroxyindoleacetic acid (5-HIAA), noradrenaline (NE) and dopamine (DA) in the hippocampus and increased the level of brain-derived neurotrophic factor (BDNF) in serum and protein expression in hippocampus. In addition, AF decreased the levels of hypothalamo-pituitary-adrenal (HPA) cascade, reduced the level of NO and cGMP in serum and inhibited the overexpression of 5-HT2AR mRNA and protein expression. Taken together, AF can modulate the NO-mediated network pathway in the hippocampus against stress-induced depressive-like behaviors. These physiological and behavioral changes allow rats to avoid potential deleterious effects of stress that may result from chronically elevated levels of glucocorticosteroids over days.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Bridged-Ring Compounds
/
Signal Transduction
/
Antidepressive Agents
/
Nitric Oxide
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
Chin J Nat Med
Year:
2020
Document type:
Article
Affiliation country:
China