Eg5 targeting agents: From new anti-mitotic based inhibitor discovery to cancer therapy and resistance.

Garcia-Saez, Isabel; Skoufias, Dimitrios A

Garcia-Saez, Isabel; Skoufias, Dimitrios A.

Affiliation

Garcia-Saez I; Université Grenoble Alpes, CNRS, CEA, Institut de Biologie Structurale (IBS), 38000 Grenoble, France.
Skoufias DA; Université Grenoble Alpes, CNRS, CEA, Institut de Biologie Structurale (IBS), 38000 Grenoble, France. Electronic address: dimitrios.skoufias@ibs.fr.

Biochem Pharmacol ; 184: 114364, 2021 02.

Article in En | MEDLINE | ID: mdl-33310050

Subject(s)

Antimitotic Agents/pharmacology; Antineoplastic Agents/pharmacology; Kinesins/antagonists & inhibitors; Kinesins/metabolism; Adenosine Triphosphate/metabolism; Animals; Antimitotic Agents/chemistry; Antimitotic Agents/pharmacokinetics; Antineoplastic Agents/pharmacokinetics; Binding Sites; Biological Products/chemistry; Biological Products/pharmacology; Clinical Trials as Topic; Drug Resistance, Neoplasm/drug effects; Drug Resistance, Neoplasm/physiology; Humans; Kinesins/chemistry; Molecular Targeted Therapy/methods

Key words

Antimitotic drugs; Drug discovery; Eg5; Kinesin motors; Microtubules

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Kinesins / Antimitotic Agents / Antineoplastic Agents Limits: Animals / Humans Language: En Journal: Biochem Pharmacol Year: 2021 Document type: Article Affiliation country: France

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