Nimbolide ameliorates pancreatic inflammation and apoptosis by modulating NF-&#954;B/SIRT1 and apoptosis signaling in acute pancreatitis model.

Bansod, Sapana; Godugu, Chandraiah

Nimbolide ameliorates pancreatic inflammation and apoptosis by modulating NF-κB/SIRT1 and apoptosis signaling in acute pancreatitis model.

Bansod, Sapana; Godugu, Chandraiah.

Affiliation

Bansod S; Department of Regulatory Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Balanagar, Hyderabad, Telangana, India.
Godugu C; Department of Regulatory Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Balanagar, Hyderabad, Telangana, India. Electronic address: chandraiah@niperhyd.ac.in.

Int Immunopharmacol ; 90: 107246, 2021 Jan.

Article in En | MEDLINE | ID: mdl-33310297

Subject(s)

Apoptosis/drug effects; Limonins/therapeutic use; NF-kappa B; Pancreatitis/drug therapy; Signal Transduction/drug effects; Sirtuin 1; Animals; Ceruletide/pharmacology; Edema/pathology; Edema/prevention & control; Injections, Intraperitoneal; Limonins/pharmacology; Male; Mice; Oxidative Stress/drug effects; Pancreas/pathology; Pancreatitis/pathology; RAW 264.7 Cells; alpha-Amylases/metabolism

Key words

Acute pancreatitis (AP); Apoptosis; Inflammation; Nimbolide (NB); SIRT1

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pancreatitis / Signal Transduction / NF-kappa B / Apoptosis / Limonins / Sirtuin 1 Type of study: Prognostic_studies Limits: Animals Language: En Journal: Int Immunopharmacol Journal subject: ALERGIA E IMUNOLOGIA / FARMACOLOGIA Year: 2021 Document type: Article Affiliation country: India Country of publication: Netherlands

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