[A case of the successful treatment of severe myoclonus with Lance-Adams syndrome by add-on perampanel showing long term effects].
Rinsho Shinkeigaku
; 61(1): 18-23, 2021 Jan 29.
Article
in Ja
| MEDLINE
| ID: mdl-33328418
ABSTRACT
Perampanel is an α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor antagonist that has been marked as an antiepileptic drug for partial-onset and primary generalized tonic-clonic seizures. There have been some recent reports of perampanel being effective against cortical myoclonus by Lafora disease and Unverricht-Lundborg disease. We herein report a 49-year-old man who presented with myoclonus due to Lance-Adams syndrome (LAS) after cardiopulmonary arrest caused by a severe bronchial asthma attack. Perampanel was very effective against myoclonus induced by LAS even in the chronic state, over 10 years after the remote onset. Perampanel should be considered for the treatment of extremely refractory myoclonus due to LAS.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pyridones
/
Receptors, AMPA
/
Lafora Disease
/
Unverricht-Lundborg Syndrome
/
Anticonvulsants
/
Myoclonus
Type of study:
Etiology_studies
Limits:
Humans
/
Male
/
Middle aged
Language:
Ja
Journal:
Rinsho Shinkeigaku
Year:
2021
Document type:
Article