Loss of p27Kip1 leads to expansion of CD4+ effector memory T cells and accelerates colitis-associated colon cancer in mice with a T cell lineage restricted deletion of Smad4.

Choi, Sung Hee; Barker, Emily C; Gerber, Kyle J; Letterio, John J; Kim, Byung-Gyu

Choi, Sung Hee; Barker, Emily C; Gerber, Kyle J; Letterio, John J; Kim, Byung-Gyu.

Affiliation

Choi SH; Department of Pediatrics, Case Western Reserve University, Cleveland, OH, USA.
Barker EC; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio, USA.
Gerber KJ; Department of Pediatrics, Case Western Reserve University, Cleveland, OH, USA.
Letterio JJ; Department of Chemistry, Case Western Reserve University, Cleveland, Ohio, USA.
Kim BG; Department of Pediatrics, Case Western Reserve University, Cleveland, OH, USA.

Oncoimmunology ; 9(1): 1847832, 2020 12 03.

Article in En | MEDLINE | ID: mdl-33329939

Subject(s)

Colitis-Associated Neoplasms; Immunologic Memory; Animals; CD4-Positive T-Lymphocytes; Cell Lineage; Cyclin-Dependent Kinase Inhibitor p27/genetics; Mice

Key words

CD4 effector T cell; Smad4; colitis-associated colon cancer; p27kip1

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Colitis-Associated Neoplasms / Immunologic Memory Type of study: Risk_factors_studies Limits: Animals Language: En Journal: Oncoimmunology Year: 2020 Document type: Article Affiliation country: United States

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