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An IMiD-inducible degron provides reversible regulation for chimeric antigen receptor expression and activity.
Carbonneau, Seth; Sharma, Sujata; Peng, Liaomin; Rajan, Vaisakh; Hainzl, Dominik; Henault, Martin; Yang, Chian; Hale, Jacob; Shulok, Janine; Tallarico, John; Porter, Jeff; Brogdon, Jennifer L; Dranoff, Glenn; Bradner, James E; Hild, Marc; Guimaraes, Carla P.
Affiliation
  • Carbonneau S; Novartis Institutes for Biomedical Research, Cambridge, MA, USA.
  • Sharma S; Novartis Institutes for Biomedical Research, Cambridge, MA, USA.
  • Peng L; Novartis Institutes for Biomedical Research, Cambridge, MA, USA.
  • Rajan V; Novartis Institutes for Biomedical Research, Cambridge, MA, USA.
  • Hainzl D; Novartis Institutes for Biomedical Research, Cambridge, MA, USA.
  • Henault M; Novartis Institutes for Biomedical Research, Cambridge, MA, USA.
  • Yang C; Novartis Institutes for Biomedical Research, Cambridge, MA, USA.
  • Hale J; Novartis Institutes for Biomedical Research, Cambridge, MA, USA.
  • Shulok J; Novartis Institutes for Biomedical Research, Cambridge, MA, USA.
  • Tallarico J; Novartis Institutes for Biomedical Research, Cambridge, MA, USA.
  • Porter J; Novartis Institutes for Biomedical Research, Cambridge, MA, USA.
  • Brogdon JL; Novartis Institutes for Biomedical Research, Cambridge, MA, USA.
  • Dranoff G; Novartis Institutes for Biomedical Research, Cambridge, MA, USA.
  • Bradner JE; Novartis Institutes for Biomedical Research, Cambridge, MA, USA.
  • Hild M; Novartis Institutes for Biomedical Research, Cambridge, MA, USA. Electronic address: marc.hild@novartis.com.
  • Guimaraes CP; Novartis Institutes for Biomedical Research, Cambridge, MA, USA. Electronic address: carla.guimaraes@novartis.com.
Cell Chem Biol ; 28(6): 802-812.e6, 2021 06 17.
Article in En | MEDLINE | ID: mdl-33333026
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: T-Lymphocytes / Ikaros Transcription Factor / Receptors, Chimeric Antigen / Immunologic Factors Type of study: Prognostic_studies Limits: Adolescent / Adult / Animals / Female / Humans / Male / Middle aged Language: En Journal: Cell Chem Biol Year: 2021 Document type: Article Affiliation country: United States Country of publication: United States
Fulltext
Add to My VHL
Print
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: T-Lymphocytes / Ikaros Transcription Factor / Receptors, Chimeric Antigen / Immunologic Factors Type of study: Prognostic_studies Limits: Adolescent / Adult / Animals / Female / Humans / Male / Middle aged Language: En Journal: Cell Chem Biol Year: 2021 Document type: Article Affiliation country: United States Country of publication: United States