Drug-induced cutaneous vasculitis and anticoagulant-related cutaneous adverse reactions: insights in pathogenesis, clinical presentation, and treatment.
Clin Dermatol
; 38(6): 613-628, 2020.
Article
in En
| MEDLINE
| ID: mdl-33341196
ABSTRACT
Drug-induced vasculitis and anticoagulant-related skin reactions are commonly encountered in the inpatient and outpatient settings. The spectrum of clinical presentation is broad and ranges from focal, skin-limited disease, to more extensive cutaneous and soft tissue necrosis, to potentially fatal systemic involvement. The prompt recognition of these adverse events can have a significant impact on patient morbidity and mortality. We highlight the key features of the clinical presentation with an emphasis on primary lesion morphology, distribution, and epidemiology of purpuric drug reactions. The proposed pathophysiology, histologic findings, and therapeutic interventions of these potentially life-threatening diseases are discussed.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Purpura
/
Vasculitis
/
Skin Diseases, Vascular
Type of study:
Etiology_studies
Limits:
Humans
Language:
En
Journal:
Clin Dermatol
Year:
2020
Document type:
Article