Heparin locks with low and high concentration in haemodialysis patients: A systematic review and meta-analysis.
Int J Nurs Pract
; 27(1): e12907, 2021 Feb.
Article
in En
| MEDLINE
| ID: mdl-33347670
ABSTRACT
AIM:
There is no evidence-based consensus on the optimal concentration for heparin locks; several randomized controlled trials (RCTs) have evaluated the concentration of heparin locks, yet the results remain inconsistent. We aimed to assess heparin locks with low and high concentration in haemodialysis patients.METHODS:
We performed a systematic review and meta-analysis of RCTs focusing on the concentration in heparin locks. Studies were identified by searching PUBMED, EMBASE, Science Direct, Cochrane Central Register of Controlled Trials, China National Knowledge Infrastructure (CNKI) and Wanfang databases (from inception to 15 March 2020). Summary risk ratios or mean differences with 95% confidence interval were calculated.RESULTS:
A total of 370 patients with four RCTs were included. Heparin locks with 1000 U/ml could significantly reduce the activated partial thromboplastin time (APTT) compared with 5000 U/ml. No significant differences were seen in the occurrence of catheter-related thrombosis, the length of catheter stay, the rates of bleeding and catheter occlusions between the two groups.CONCLUSIONS:
Lower concentrations in heparin lock are optimal for shortening APTT in haemodialysis patients; further studies are needed to elucidate the role of heparin concentration in the lock practice.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Heparin
/
Renal Dialysis
/
Anticoagulants
Type of study:
Clinical_trials
/
Systematic_reviews
Limits:
Humans
Country/Region as subject:
Asia
Language:
En
Journal:
Int J Nurs Pract
Journal subject:
ENFERMAGEM
Year:
2021
Document type:
Article
Affiliation country:
China