The Ercc<i>1</i><sup>-/&#916;</sup> mouse model of accelerated senescence and aging for identification and testing of novel senotherapeutic interventions.

Wong, Alec; Kieu, Tra; Robbins, Paul D

The Ercc1^-/Δ mouse model of accelerated senescence and aging for identification and testing of novel senotherapeutic interventions.

Wong, Alec; Kieu, Tra; Robbins, Paul D.

Affiliation

Wong A; Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.
Kieu T; Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.
Robbins PD; Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.

Aging (Albany NY) ; 12(24): 24481-24483, 2020 12 22.

Article in En | MEDLINE | ID: mdl-33353886

Subject(s)

Aging/genetics; Apoptosis/genetics; DNA-Binding Proteins/genetics; Disease Models, Animal; Endonucleases/genetics; Mice; Aging/drug effects; Animals; Apoptosis/drug effects; Cellular Senescence/drug effects; Cellular Senescence/genetics; Cockayne Syndrome/genetics; Cockayne Syndrome/physiopathology; DNA Damage/genetics; Flavonols/pharmacology; Xeroderma Pigmentosum/genetics; Xeroderma Pigmentosum/physiopathology

Key words

DNA damage; DNA repair; aging; cellular senescence; senolytic

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Aging / Apoptosis / Disease Models, Animal / DNA-Binding Proteins / Endonucleases / Mice Type of study: Diagnostic_studies Limits: Animals Language: En Journal: Aging (Albany NY) Journal subject: GERIATRIA Year: 2020 Document type: Article Affiliation country: United States

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