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Temperature-Dependent Reactivity of a Non-heme FeIII(OH)(SR) Complex: Relevance to Isopenicillin N Synthase.
Yadav, Vishal; Siegler, Maxime A; Goldberg, David P.
Affiliation
  • Yadav V; Department of Chemistry, The Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland 21218, United States.
  • Siegler MA; Department of Chemistry, The Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland 21218, United States.
  • Goldberg DP; Department of Chemistry, The Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland 21218, United States.
J Am Chem Soc ; 143(1): 46-52, 2021 01 13.
Article in En | MEDLINE | ID: mdl-33356198
ABSTRACT
Non-heme iron complexes with cis-FeIII(OH)(SAr/OAr) coordination were isolated and examined for their reactivity with a tertiary carbon radical. The sulfur-ligated complex shows a temperature dependence on •OH versus ArS• transfer, whereas the oxygen-ligated complex does not. These results provide the first working model for C-S bond formation in isopenicillin N synthase and indicate that kinetic control may be a key factor in the selectivity of non-heme iron "rebound" processes.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oxidoreductases / Coordination Complexes Type of study: Prognostic_studies Language: En Journal: J Am Chem Soc Year: 2021 Document type: Article Affiliation country: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oxidoreductases / Coordination Complexes Type of study: Prognostic_studies Language: En Journal: J Am Chem Soc Year: 2021 Document type: Article Affiliation country: United States