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mRNA loading into ATP-responsive polyplex micelles with optimal density of phenylboronate ester crosslinking to balance robustness in the biological milieu and intracellular translational efficiency.
Yoshinaga, Naoto; Uchida, Satoshi; Dirisala, Anjaneyulu; Naito, Mitsuru; Osada, Kensuke; Cabral, Horacio; Kataoka, Kazunori.
Affiliation
  • Yoshinaga N; Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.
  • Uchida S; Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan; Innovation Center of NanoMedicine (iCONM), Kawasaki Institute of Industrial Promotion, 3-25-14 Tonomachi, Kawasaki-ku, Kawasaki 210-0821, Japan. Electronic address: s
  • Dirisala A; Innovation Center of NanoMedicine (iCONM), Kawasaki Institute of Industrial Promotion, 3-25-14 Tonomachi, Kawasaki-ku, Kawasaki 210-0821, Japan.
  • Naito M; Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
  • Osada K; Quantum Medical Science Directorate, National Institutes for Quantum and Radiological Science and Technology (QST), 4-9-1 Anagawa, Inage-ku, Chiba-shi, Chiba 263-8555, Japan.
  • Cabral H; Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.
  • Kataoka K; Innovation Center of NanoMedicine (iCONM), Kawasaki Institute of Industrial Promotion, 3-25-14 Tonomachi, Kawasaki-ku, Kawasaki 210-0821, Japan; Institute for Future Initiatives, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. Electronic address: kataoka@ifi.u-tokyo.ac.jp.
J Control Release ; 330: 317-328, 2021 02 10.
Article in En | MEDLINE | ID: mdl-33359053
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Esters / Micelles Language: En Journal: J Control Release Journal subject: FARMACOLOGIA Year: 2021 Document type: Article Affiliation country: Japan Country of publication: Netherlands
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Esters / Micelles Language: En Journal: J Control Release Journal subject: FARMACOLOGIA Year: 2021 Document type: Article Affiliation country: Japan Country of publication: Netherlands