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Genetically Engineered Mouse Model of Brainstem High-Grade Glioma.
Nunez, Fernando M; Gauss, Jessica C; Mendez, Flor M; Haase, Santiago; Lowenstein, Pedro R; Castro, Maria G.
Affiliation
  • Nunez FM; Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
  • Gauss JC; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
  • Mendez FM; Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
  • Haase S; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
  • Lowenstein PR; Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
  • Castro MG; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
STAR Protoc ; 1(3): 100165, 2020 12 18.
Article in En | MEDLINE | ID: mdl-33377059
ABSTRACT
Brainstem gliomas are aggressive tumors that are more prevalent in pediatric patients. The location of these tumors makes them inoperable, and currently there is no effective treatment. Recent genomic data revealed the unique biology of these tumors. The following protocol provides a method to incorporate these specific genetic lesions in a mouse glioma model. Using this model, the effects of these mutations in tumor progression and response to treatments can be studied within a relevant in vivo context. For complete details on the use and execution of this protocol, please refer to Mendez et al. (2020).
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Genetic Engineering / Brain Stem Neoplasms / Glioma Type of study: Guideline / Prognostic_studies Limits: Animals / Humans Language: En Journal: STAR Protoc Year: 2020 Document type: Article Affiliation country: United States
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Genetic Engineering / Brain Stem Neoplasms / Glioma Type of study: Guideline / Prognostic_studies Limits: Animals / Humans Language: En Journal: STAR Protoc Year: 2020 Document type: Article Affiliation country: United States