A CD209 ligand and a sialidase inhibitor differentially modulate adipose tissue and liver macrophage populations and steatosis in mice on the Methionine and Choline-Deficient (MCD) diet.

Pilling, Darrell; Karhadkar, Tejas R; Gomer, Richard H

Pilling, Darrell; Karhadkar, Tejas R; Gomer, Richard H.

Affiliation

Pilling D; Department of Biology, Texas A&M University, College Station, TX, United States of America.
Karhadkar TR; Department of Biology, Texas A&M University, College Station, TX, United States of America.
Gomer RH; Department of Biology, Texas A&M University, College Station, TX, United States of America.

PLoS One ; 15(12): e0244762, 2020.

Article in En | MEDLINE | ID: mdl-33378413

Subject(s)

Adipose Tissue/drug effects; Cell Adhesion Molecules/agonists; Lectins, C-Type/agonists; Liver/drug effects; Macrophages/drug effects; N-Acetylneuraminic Acid/analogs & derivatives; Neuraminidase/antagonists & inhibitors; Receptors, Cell Surface/agonists; Adipose Tissue/metabolism; Animals; Choline Deficiency/metabolism; Diabetes Mellitus, Type 2/metabolism; Disease Models, Animal; Fatty Liver/drug therapy; Fatty Liver/metabolism; Inflammation/metabolism; Liver/metabolism; Macrophages/metabolism; Mice; N-Acetylneuraminic Acid/pharmacology; N-Acetylneuraminic Acid/therapeutic use; Neuraminidase/metabolism; Non-alcoholic Fatty Liver Disease/drug therapy; Non-alcoholic Fatty Liver Disease/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cell Adhesion Molecules / Adipose Tissue / Receptors, Cell Surface / N-Acetylneuraminic Acid / Lectins, C-Type / Liver / Macrophages / Neuraminidase Limits: Animals Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2020 Document type: Article Affiliation country: United States Country of publication: United States

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