Carbohydrate-based adjuvants.
Drug Discov Today Technol
; 35-36: 57-68, 2020 Dec.
Article
in En
| MEDLINE
| ID: mdl-33388128
ABSTRACT
Carbohydrate adjuvants are safe and biocompatible compounds usable as sustained delivery systems and stimulants of ongoing humoral and cellular immune responses, being especially suitable for the development of vaccines against intracellular pathogens where alum is useless. The development of new adjuvants is difficult and expensive, however, in the last two years, seven new carbohydrate-based adjuvants have been patented, also there are twelve ongoing clinical trials of vaccines that contain carbohydrate-based adjuvants, as well as numerous publications on their mechanism of action and safety. More research is necessary to improve the existent adjuvants and develop innovative ones.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Carbohydrates
/
Adjuvants, Immunologic
/
Vaccination
Type of study:
Prognostic_studies
Limits:
Animals
/
Humans
Language:
En
Journal:
Drug Discov Today Technol
Year:
2020
Document type:
Article