Transient receptor potential vanilloid 4 activation inhibits the delayed rectifier potassium channels in hippocampal pyramidal neurons: An implication in pathological changes following pilocarpine-induced status epilepticus.

Zhou, Li; Xu, Weixing; An, Dong; Sha, Sha; Men, Chen; Li, Yingchun; Wang, Xiaoli; Du, Yimei; Chen, Lei

Zhou, Li; Xu, Weixing; An, Dong; Sha, Sha; Men, Chen; Li, Yingchun; Wang, Xiaoli; Du, Yimei; Chen, Lei.

Affiliation

Zhou L; Department of Physiology, Nanjing Medical University, Nanjing, P.R. China.
Xu W; Department of Physiology, Nanjing Medical University, Nanjing, P.R. China.
An D; Department of Physiology, Nanjing Medical University, Nanjing, P.R. China.
Sha S; Department of Physiology, Nanjing Medical University, Nanjing, P.R. China.
Men C; Department of Geriatrics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, P.R. China.
Li Y; Department of Physiology, Nanjing Medical University, Nanjing, P.R. China.
Wang X; Department of Physiology, Nanjing Medical University, Nanjing, P.R. China.
Du Y; Research Center of Ion Channelopathy, Institute of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R. China.
Chen L; Department of Physiology, Nanjing Medical University, Nanjing, P.R. China.

J Neurosci Res ; 99(3): 914-926, 2021 03.

Article in En | MEDLINE | ID: mdl-33393091

Subject(s)

Delayed Rectifier Potassium Channels/metabolism; Pyramidal Cells/physiology; Status Epilepticus/physiopathology; TRPV Cation Channels/metabolism; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2/metabolism; Delayed Rectifier Potassium Channels/pharmacology; Hippocampus/metabolism; Hippocampus/physiology; Leucine/analogs & derivatives; Leucine/pharmacology; Male; Mice; Mice, Inbred ICR; Morpholines/pharmacology; Pilocarpine; Pyramidal Cells/metabolism; Pyrroles/pharmacology; Status Epilepticus/chemically induced; Sulfonamides/pharmacology; TRPV Cation Channels/antagonists & inhibitors

Key words

Kv subunit expression; RRID: SCR_003070 (ImageJ software); RRID: SCR_012763 (STATA software); RRID:AB_10673392 (Kv2.1 antibody); RRID:AB_2040144 (Kv1.1 antibody); RRID:AB_2313792 (Kv1.2 antibody); RRID:AB_2630358 (GAPDH antibody); hippocampus; pilocarpine-induced status epilepticus; transient receptor potential vanilloid 4; voltage-gated potassium channel

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Status Epilepticus / Pyramidal Cells / Delayed Rectifier Potassium Channels / TRPV Cation Channels Limits: Animals Language: En Journal: J Neurosci Res Year: 2021 Document type: Article Country of publication: United States

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